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ChemicalBook > Product Catalogue >Biochemical Engineering >Amino Acids and Derivatives >Glutamic acid derivatives >D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT

D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT

D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT Structure
  • ₹5098.58 - ₹62720.05
  • Product name: D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT
  • CAS: 103404-90-6
  • MF: C5H9NaO5
  • MW: 172.11
  • EINECS:
  • MDL Number:MFCD00069573
  • Synonyms:D-alpha-Hydroxyglutaric acid disodiuM salt >=95% (GC);Disodium (R)-2-hydroxyglutarate;D-α-Hydroxyglutaric Acid (sodium salt);D-ALPHA-HYDROXYGLUTARIC ACID DISODIU;D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT;D-ALPHA-HYDROXYGLUTARIC ACID DISODIUM SALT;D-A-HYDROXYGLUTARIC ACID DISODIUM;(r)-2-hydroxypentanedioic acid
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  • Sigma-Aldrich(India)

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  • 10MG
  • 50MG
  • 100MG
  • 250MG
  • ManufacturerSigma-Aldrich(India)
  • Product number16859
  • Product descriptionD-α-Hydroxyglutaric acid disodium salt ≥98.0% (GC)
  • Packaging10MG
  • Price₹5098.58
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number16859
  • Product descriptionD-α-Hydroxyglutaric acid disodium salt ≥98.0% (GC)
  • Packaging50MG
  • Price₹20361.83
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberH8378
  • Product descriptionD-α-Hydroxyglutaric acid disodium salt ≥95% (GC)
  • Packaging100MG
  • Price₹31295.08
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberH8378
  • Product descriptionD-α-Hydroxyglutaric acid disodium salt ≥95% (GC)
  • Packaging250MG
  • Price₹52815.18
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number16859
  • Product descriptionD-α-Hydroxyglutaric acid disodium salt ≥98.0% (GC)
  • Packaging250MG
  • Price₹62720.05
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 16859 D-α-Hydroxyglutaric acid disodium salt ≥98.0% (GC) 10MG ₹5098.58 2022-06-14 Buy
Sigma-Aldrich(India) 16859 D-α-Hydroxyglutaric acid disodium salt ≥98.0% (GC) 50MG ₹20361.83 2022-06-14 Buy
Sigma-Aldrich(India) H8378 D-α-Hydroxyglutaric acid disodium salt ≥95% (GC) 100MG ₹31295.08 2022-06-14 Buy
Sigma-Aldrich(India) H8378 D-α-Hydroxyglutaric acid disodium salt ≥95% (GC) 250MG ₹52815.18 2022-06-14 Buy
Sigma-Aldrich(India) 16859 D-α-Hydroxyglutaric acid disodium salt ≥98.0% (GC) 250MG ₹62720.05 2022-06-14 Buy

Properties

Melting point :>291°C (dec.)
storage temp. :-20°C
solubility :PBS (pH 7.2): 10 mg/ml
form :A crystalline solid
color :White to light yellow
optical activity :[α]/D 8.5±1.5°, c = 1 in NaOH
Water Solubility :Soluble to 100 mM in water
BRN :5318041
Stability :Hygroscopic
InChIKey :DZHFTEDSQFPDPP-HWYNEVGZSA-L

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Description

D-α-Hydroxyglutaric Acid (D-2-HG) is an α-hydroxy acid that is over-produced in the human neurometabolic disease D-2-hydroxyglutaric aciduria (D-2-HGA). It is normally synthesized from 2-ketoglutarate (2-KG) by hydroxyacid-oxoacid transhydrogenase (HOT), although defects in HOT are not known to be associated with D-2-HGA. Instead, type I D-2-HGA involves mutations in D-2-hydroxyglutarate dehydrogenase, which converts D-2-HG back to 2-KG. Type II D-2-HGA results from gain-of-function mutations in isocitrate dehydrogenase 2, causing it to supplement HOT in converting 2-KG to D-2-HG. In bacteria, this α-hydroxy acid may be synthesized from oxalate and propionyl-coenzyme A by an α-hydroxyglutaric acid synthetase.

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