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1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid

1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid Structure
  • ₹15280 - ₹86383.5
  • Product name: 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
  • CAS: 1160514-60-2
  • MF: C16H11Cl3F3N3O3
  • MW: 456.63
  • EINECS:
  • MDL Number:MFCD00178741
  • Synonyms:1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid;Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate;TRPC3 Channel Inhibitor, Pyr3 ;1-[4-(2,3,3-Trichloro-acryloylamino)-phenyl]-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester;TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem;1H-Pyrazole-4-carboxylic acid, 1-[4-[(2,3,3-trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-, ethyl ester;Pyr3;Pyr3,Pyr-3
Price3 Properties Safety Information Description
3 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product number648490
  • Product descriptionTRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem The TRPC3 Channel Inhibitor, Pyr3, also referenced under CAS 1160514-60-2, controls the biological activity of TRPC3 Channel. This small molecule/inhi
  • Packaging10MG
  • Price₹15280
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP0032
  • Product descriptionPyr3 ≥98% (HPLC)
  • Packaging25MG
  • Price₹86383.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP0032
  • Product descriptionPyr3 ≥98% (HPLC)
  • Packaging5MG
  • Price₹21790.73
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 648490 TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem The TRPC3 Channel Inhibitor, Pyr3, also referenced under CAS 1160514-60-2, controls the biological activity of TRPC3 Channel. This small molecule/inhi 10MG ₹15280 2022-06-14 Buy
Sigma-Aldrich(India) P0032 Pyr3 ≥98% (HPLC) 25MG ₹86383.5 2022-06-14 Buy
Sigma-Aldrich(India) P0032 Pyr3 ≥98% (HPLC) 5MG ₹21790.73 2022-06-14 Buy

Properties

Melting point :151-153 °C(Solv: toluene (108-88-3))
Boiling point :534.0±50.0 °C(Predicted)
Density :1.54±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO (up to 40 mg/ml).
form :powder
pka :9.97±0.70(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Pyr3 is a pyrazole compound that selectively antagonizes the transient receptor potential canonical channel 3 (TRPC3). It inhibits TRPC3-mediated Ca2+ influx with an IC50 value of 0.7 μM without effect on other TRPC members and suppresses activation of nuclear factor of activated T cells with an IC50 value of 0.05 μM. Pyr3 has been shown to suppress cardiac hypertrophy in mice at 0.1 mg/kg/day.

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