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ChemicalBook > Product Catalogue >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Chloropyridine >2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE

2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE

2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE Structure
  • ₹1948.5 - ₹26800
  • Product name: 2-[N,N-BIS(TRIFLUOROMETHANESULFONYL)AMINO]-5-CHLOROPYRIDINE
  • CAS: 145100-51-2
  • MF: C7H3ClF6N2O4S2
  • MW: 392.68
  • EINECS:629-110-2
  • MDL Number:MFCD00191833
  • Synonyms:Comins Reagent, N,N-Bis(trifluoromethylsulfonyl)-5-chloro-2-pyridylamine, 2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine;N-(5-CHLORO-2-PYRIDYL)BIS(TRILFUOROMETHANESULFONIMIDE);2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine ,98%;Comins Triflating Reagent;N-(5-Chloro-2-pyridyl)triflimide N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonyl)imide Comins Triflating Reagent;N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoroMethane)sulfonylMethanesulfonaMide;2-{Bis[(trifluoromethyl)sulphonyl]amino}-5-chloropyridine;N-(5-Chloropyridin-2-yl)triflimide
4 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 1G
  • 5G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberB1865
  • Product description2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent] min. 96.0 %
  • Packaging5G
  • Price₹8700
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB1865
  • Product description2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent] min. 96.0 %
  • Packaging25G
  • Price₹26800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number403644
  • Product descriptionN-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide) 96%
  • Packaging1G
  • Price₹1948.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number403644
  • Product descriptionN-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide) 96%
  • Packaging5G
  • Price₹8497.63
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B1865 2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent] min. 96.0 % 5G ₹8700 2022-05-26 Buy
TCI Chemicals (India) B1865 2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent] min. 96.0 % 25G ₹26800 2022-05-26 Buy
Sigma-Aldrich(India) 403644 N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide) 96% 1G ₹1948.5 2022-06-14 Buy
Sigma-Aldrich(India) 403644 N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide) 96% 5G ₹8497.63 2022-06-14 Buy

Properties

Melting point :45-47 °C(lit.)
Boiling point :77-90°C/0.2mmHg
Density :1.892±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Benzene (Slightly)
form :Solid
pka :-7.71±0.10(Predicted)
color :yellow
Water Solubility :Reacts with water.
Sensitive :Moisture Sensitive
BRN :5833971
Stability :Moisture Sensitive, Unstable in DMSO Solution
InChIKey :TUFGVZMNGTYAQD-UHFFFAOYSA-N
CAS DataBase Reference :145100-51-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine provides good yields of vinyl triflates from the corresponding ketone enolates or dienolates. It is used in the total synthesis of (-)-porantheridine and the trans decahydroquinoline alkaloid (+)-219A. It is also used as a reactant for Suzuki-Miyaura cross coupling, synthesis of nicotinic acetylcholine receptor-selective ligands, enantioselective desymmetrizing palladium catalyzed carbonylation reactions, synthesis of high affinity niacin receptor GPR109A agonists and in preparation of heteroaromatics.

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