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(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone

(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone Structure
  • ₹0
  • Product name: (3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone
  • CAS: 149249-91-2
  • MF: C22H27NO3Si
  • MW: 381.54
  • EINECS:
  • MDL Number:MFCD08273950
  • Synonyms:(3R,4S)-1-Benzoyl-3-[(Triethyl;PACLITAXEL SIDE CHAIN/(3R,4S)-1-BENZOYL-3-[(TRIETHYLSILYL)OXY]-4-PHENYL-2-PHENYL-2-AZETIDINONE;PACLITAXEL SIDE CHAIN NO 2;(3R,4S)-1-Benzoyl-4-Phenyl-3-[(Triethylsilyl)Oxy]-2-AzetidinoneCasNo.;(3R,4S)-1-BENZOYL-3-[(TRIETHYLSILYS)OXY]-4-PHENYL-2-AZETIDINONE;(3R,4S)-3-triethylsilanyloxy-4-phenyl-N-benzoyl-2-azetidinone;(3R,4S)-1-benzoyl-4-phenyl-3- (triethylsilyloxy)azetidin-2-one;(3R,4S)-1-BENZOYL-3-[(TRIETHYLSILYL)OXY]-4-PHENYL-2-AZETIDINONE
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Properties

Boiling point :467.2±55.0 °C(Predicted)
Density :1.12
storage temp. :2-8°C
solubility :Dichloromethane, Ether, Ethyl Acetate, Methanol
form :Oil
pka :-4.66±0.60(Predicted)
color :Transparent
CAS DataBase Reference :149249-91-2(CAS DataBase Reference)

Safety Information

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Description

(3R,4S)-1-Benzoyl-4-phenyl-3-[(triethylsilyl)oxy]-2-azetidinone is an intermedaite of 10-O-[(2R,3S)-3-(Benzoylamino)-2-hydroxy-3-phenylpropanoyl]-10-O-deacetylpaclitaxel (B207800), which is an impurity in the synthesis of Paclitaxel (P132500), an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi''s sarcoma.

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