Epothilone B
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- ₹4800 - ₹22900
- Product name: Epothilone B
- CAS: 152044-54-7
- MF: C27H41NO6S
- MW: 507.68
- EINECS:604-822-6
- MDL Number:MFCD02101921
- Synonyms:Epothilone B(EPO906);Epothilone B HOUSE STANDARD;Epothilone B(Patupilone);(3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentaMethyl-3-((E)-1-(2-Methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dione;Epothilone B (EPO906, Patupilone);EPOTHILONE;(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione;Patupilone (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
5 prices
Selected condition:
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 1MG
- 5MG
- 25MG
- ManufacturerTCI Chemicals (India)
- Product numberE1378
- Product descriptionEpothilone B
- Packaging5MG
- Price₹4800
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberE2656
- Product description(−)-Epothilone B from Sorangium cellulosum, ≥98% (HPLC)
- Packaging1MG
- Price₹5260.95
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number325001
- Product descriptionEpothilone B, Synthetic A structural analog of Epothilone A with similar biological properties.
- Packaging1MG
- Price₹14970
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberE2656
- Product description(−)-Epothilone B from Sorangium cellulosum, ≥98% (HPLC)
- Packaging5MG
- Price₹15988.53
- Updated2022-06-14
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberE1378
- Product descriptionEpothilone B
- Packaging25MG
- Price₹22900
- Updated2022-05-26
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
TCI Chemicals (India) | E1378 | Epothilone B | 5MG | ₹4800 | 2022-05-26 | Buy |
Sigma-Aldrich(India) | E2656 | (−)-Epothilone B from Sorangium cellulosum, ≥98% (HPLC) | 1MG | ₹5260.95 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 325001 | Epothilone B, Synthetic A structural analog of Epothilone A with similar biological properties. | 1MG | ₹14970 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | E2656 | (−)-Epothilone B from Sorangium cellulosum, ≥98% (HPLC) | 5MG | ₹15988.53 | 2022-06-14 | Buy |
TCI Chemicals (India) | E1378 | Epothilone B | 25MG | ₹22900 | 2022-05-26 | Buy |
Properties
Melting point :95-97°C
alpha :D21 -35° (c = 0.7 in methanol)
Boiling point :680.2±55.0 °C(Predicted)
Density :1.136
storage temp. :Store at -20°C
solubility :Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 35 mg/ml).
form :White to off-white solid
pka :13.57±0.70(Predicted)
color :colorless
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey :QXRSDHAAWVKZLJ-PVYNADRNSA-N
CAS DataBase Reference :152044-54-7
alpha :D21 -35° (c = 0.7 in methanol)
Boiling point :680.2±55.0 °C(Predicted)
Density :1.136
storage temp. :Store at -20°C
solubility :Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 35 mg/ml).
form :White to off-white solid
pka :13.57±0.70(Predicted)
color :colorless
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey :QXRSDHAAWVKZLJ-PVYNADRNSA-N
CAS DataBase Reference :152044-54-7
Safety Information
Symbol(GHS): |
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Description
Epothilone B (Epo B) is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis. It induces mitotic arrest at the G2-M transition in Hs578T and HeLa cells (IC50 = 3 and 32 nM, respectively) as well as in multidrug resistant KB3-1 and KBV-1 cells (IC50 = 16 and 92 nM, respectively). Epo B causes cell cycle arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.More related product prices
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