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1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 17-GLUCURONIDE SODIUM SALT

1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 17-GLUCURONIDE SODIUM SALT Structure
  • ₹10030 - ₹79620
  • Product name: 1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 17-GLUCURONIDE SODIUM SALT
  • CAS: 15087-02-2
  • MF: C24H31NaO8
  • MW: 470.49
  • EINECS:
  • MDL Number:MFCD00056557
  • Synonyms:1,3,5(10)-ESTRATRIEN-3,17-BETA-DIOL 17-GLUCOSIDURONATE SODIUM SALT;1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 17-GLUCURONIDE SODIUM SALT;BETA-ESTRADIOL 17-(BETA-D-GLUCURONIDE) SODIUM SALT;oestradiol 17-(beta-D-glucuronide), sodium salt;1,3,5(10)-Estratriene-3,17β-diol 17-glucuronide, 3,17β-Dihydroxy-1,3,5(10)-estratriene 17-glucuronide;β-Estradiol 17-(β-D-glucuronide) sodium salt;1,3,5(10)-Estratriene-3,17β-diol 17-glucuronide;3,17β-Dihydroxy-1,3,5(10)-estratriene 17-glucuronide
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 25MG
  • 100MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberE1127
  • Product descriptionβ-Estradiol 17-(β-D-glucuronide) sodium salt
  • Packaging5MG
  • Price₹10030
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberE1127
  • Product descriptionβ-Estradiol 17-(β-D-glucuronide) sodium salt
  • Packaging10MG
  • Price₹16400
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberE1127
  • Product descriptionβ-Estradiol 17-(β-D-glucuronide) sodium salt
  • Packaging25MG
  • Price₹29680
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberE1127
  • Product descriptionβ-Estradiol 17-(β-D-glucuronide) sodium salt
  • Packaging100MG
  • Price₹79620
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) E1127 β-Estradiol 17-(β-D-glucuronide) sodium salt 5MG ₹10030 2022-06-14 Buy
Sigma-Aldrich(India) E1127 β-Estradiol 17-(β-D-glucuronide) sodium salt 10MG ₹16400 2022-06-14 Buy
Sigma-Aldrich(India) E1127 β-Estradiol 17-(β-D-glucuronide) sodium salt 25MG ₹29680 2022-06-14 Buy
Sigma-Aldrich(India) E1127 β-Estradiol 17-(β-D-glucuronide) sodium salt 100MG ₹79620 2022-06-14 Buy

Properties

Melting point :>245°C (dec.)
storage temp. :−20°C
solubility :DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Methanol (Slightly)
form :Solid
color :White to Off-White
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile. It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km = 75 μM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow. In addition to binding to the MRP2 transport site, E217G has been shown to bind to an allosteric site that through positive cooperativity activates its own transport via MRP2 and the transport of other MRP2 substrates, including the non-cholestatic estrogen metabolite, estradiol 3-(β-D-glucuronide) (E23G; ). E217G has also been reported to be transported by MDR1, MRP1, MRP3, MRP4, MRP7, ABCG2 (a breast cancer resistance protein transporter), and the rat organic anion-transporting polypeptides 1-4.

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