2-Acetylphenothiazine
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- ₹5880 - ₹27800
- Product name: 2-Acetylphenothiazine
- CAS: 6631-94-3
- MF: C14H11NOS
- MW: 241.31
- EINECS:229-626-4
- MDL Number:MFCD00005017
- Synonyms:2-ACETYLPHENOTHIAZINE;methyl phenothiazin-2-yl ketone;2-Acetyl-10H-phenothiazine;2-Acetylphenothiazin;1-(10H-Phenothiazin-2-yl)ethan-1- one, 2-Ethanoyl-10H-phenothiazine;ML 171;LABOTEST-BB LT00012652;NOX1 Inhibitor, ML171
5 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
- TCI Chemicals (India)
Package
- 10MG
- 5G
- 25G
- 100G
- ManufacturerSigma-Aldrich(India)
- Product number492002
- Product descriptionNOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem The NOX1 Inhibitor, ML171, also referenced under CAS 6631-94-3, controls the biological activity of NOX1.
- Packaging10MG
- Price₹5880
- Updated2022-06-14
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberA2815
- Product description2-Acetylphenothiazine min. 98.0 %
- Packaging5G
- Price₹6400
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number175226
- Product description2-Acetylphenothiazine 95%
- Packaging25G
- Price₹9233.73
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number175226
- Product description2-Acetylphenothiazine 95%
- Packaging100G
- Price₹20318.53
- Updated2022-06-14
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberA2815
- Product description2-Acetylphenothiazine min. 98.0 %
- Packaging25G
- Price₹27800
- Updated2022-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 492002 | NOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem The NOX1 Inhibitor, ML171, also referenced under CAS 6631-94-3, controls the biological activity of NOX1. | 10MG | ₹5880 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A2815 | 2-Acetylphenothiazine min. 98.0 % | 5G | ₹6400 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | 175226 | 2-Acetylphenothiazine 95% | 25G | ₹9233.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 175226 | 2-Acetylphenothiazine 95% | 100G | ₹20318.53 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A2815 | 2-Acetylphenothiazine min. 98.0 % | 25G | ₹27800 | 2022-05-26 | Buy |
Properties
Melting point :180-185 °C (lit.)
Boiling point :455.7±34.0 °C(Predicted)
Density :1.249±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :-2.45±0.20(Predicted)
form :Dark yellow-orange powder
color :Yellow to Dark Orange
λmax :244nm(MeOH)(lit.)
CAS DataBase Reference :6631-94-3(CAS DataBase Reference)
Boiling point :455.7±34.0 °C(Predicted)
Density :1.249±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :-2.45±0.20(Predicted)
form :Dark yellow-orange powder
color :Yellow to Dark Orange
λmax :244nm(MeOH)(lit.)
CAS DataBase Reference :6631-94-3(CAS DataBase Reference)
Safety Information
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Description
2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC50 value of 0.129 μM. It does not affect xanthine oxidase-dependent or mitochondrial ROS generation. 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells. It also abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM), preventing platelet aggregation and thrombus formation. 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1. 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 μM.Related product price
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