BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE
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- Product name: BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE
- CAS: 200626-61-5
- MF: C13H7Cl2N3O
- MW: 292.12
- EINECS:
- MDL Number:MFCD00195103
- Synonyms:IFLAB-BB F0451-3184;BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE;1-(2,4-Dichlorobenzoyl)-1H-benzotriazole;ITSA-1(ITSA1);CS-2249;Methanone, 1H-benzotriazol-1-yl(2,4-dichlorophenyl)-;(1H-Benzo[d][1,2,3]triazol-1-yl)(2,4-dichlorophenyl)methanone;inhibit,Histone deacetylases,ITSA-1,Inhibitor,HDAC,ITSA 1
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Properties
Melting point :119-121°C
storage temp. :Inert atmosphere,2-8°C
solubility :DMSO: ~28mg/mL
form :solid
color :White to Off-White
storage temp. :Inert atmosphere,2-8°C
solubility :DMSO: ~28mg/mL
form :solid
color :White to Off-White
Safety Information
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Description
Trichostatin A (TSA; ) is a potent, reversible inhibitor of histone deacetylase (HDAC) that inhibits HDAC1 (IC50 = 70 nM) in Jurkat cells, resulting in cell cycle arrest. ITSA1 is a cell-permeable benzotriazole amide that blocks TSA action, reducing TSA-induced acetylation of histone and tubulin in A549 cells when given at 50 μM. At the same concentration, ITSA1 also prevents TSA-mediated cell cycle arrest and apoptosis. It similarly blocks the action of the HDAC inhibitor SAHA , preventing SAHA-induced hyperacetylation of tubulin in A549 cells. ITSA1 reduces TSA-regulated transcription in mouse embryonic stem cells and in zebrafish.More related product prices
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