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2-AMINO-2-NORBORNANECARBOXYLIC ACID

2-AMINO-2-NORBORNANECARBOXYLIC ACID Structure
  • ₹7241.93 - ₹30851.25
  • Product name: 2-AMINO-2-NORBORNANECARBOXYLIC ACID
  • CAS: 20448-79-7
  • MF: C8H13NO2
  • MW: 155.19
  • EINECS:
  • MDL Number:MFCD00167580
  • Synonyms:2-AMINO-2-NORBORNANECARBOXYLIC ACID;2-AMINOBICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID;BCH;2-AMINO-2-NORBORNANECARBOXYLIC ACID, 98% , MIXTURE OF ISOMERS;2-Amino-2-carboxy-bicyclo-2,2,1-heptane;2-Aminonorbornane-2-carboxylic acid;B-Bch;Bicyclo(2.2.1)heptane-2-carboxylic acid, 2-amino-
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 100MG
  • 250MG
  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product numberA7902
  • Product description2-Amino-2-norbornanecarboxylic acid amino acid transport inhibitor
  • Packaging100MG
  • Price₹7241.93
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA7902
  • Product description2-Amino-2-norbornanecarboxylic acid amino acid transport inhibitor
  • Packaging250MG
  • Price₹11810.08
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA7902
  • Product description2-Amino-2-norbornanecarboxylic acid amino acid transport inhibitor
  • Packaging1G
  • Price₹30851.25
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) A7902 2-Amino-2-norbornanecarboxylic acid amino acid transport inhibitor 100MG ₹7241.93 2022-06-14 Buy
Sigma-Aldrich(India) A7902 2-Amino-2-norbornanecarboxylic acid amino acid transport inhibitor 250MG ₹11810.08 2022-06-14 Buy
Sigma-Aldrich(India) A7902 2-Amino-2-norbornanecarboxylic acid amino acid transport inhibitor 1G ₹30851.25 2022-06-14 Buy

Properties

Melting point :>300 °C(lit.)
Boiling point :295.5±23.0 °C(Predicted)
Density :1.256±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :Aqueous Acid (Slightly)
form :Solid
pka :2.58±0.20(Predicted)
color :White
Water Solubility :Soluble to 100 mM in water
CAS DataBase Reference :20448-79-7(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The L-type amino acid transporters (LATs) are Na+-dependent neutral amino acid transporters. They include four members in two sub-families, with LAT1 and LAT2 belonging to solute carrier (SLC) family 7 and LAT3 and LAT4 being members of SLC43. LAT1 is overexpressed in many tumors and contributes to ribosome biogenesis and cell growth by supporting mTOR complex 1 (mTORC1) signaling. BCH is an inhibitor of LAT1 that blocks the uptake of L-leucine with an IC50 value of 131.5 μM. It can inhibit all members of the LAT family at a concentration of 10 mM. In addition to eliminating the uptake of neutral amino acids, BCH suppresses mTORC1 signaling that drives DNA synthesis and cell proliferation. LAT1 is also essential for the uptake of amino acid-related compounds, like L-DOPA , through the blood-brain barrier, and this can be inhibited by BCH.

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