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(S)-N-Fmoc-2-(2'-propylenyl)alanine

(S)-N-Fmoc-2-(2'-propylenyl)alanine Structure
  • ₹0
  • Product name: (S)-N-Fmoc-2-(2'-propylenyl)alanine
  • CAS: 288617-71-0
  • MF: C21H21NO4
  • MW: 351.4
  • EINECS:
  • MDL Number:MFCD02682444
  • Synonyms:(S)-N-Fmoc-2-(2'-propylenyl)alanine;(2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-4-pentenoic acid;(S)-N-Fmoc-alpha-allylalanine;(S)-N-(9-Fluorenylmethylcarbamate)-2-(2'-propylenyl)alanine;Fmoc-alpha-methyl-L-allylglycine;(S)-N-FMOC-Α-ALLYLALANINE;FMoc-α-Me-Gly(Allyl)-OH;(S)-N-Fmoc-α-2-n-propenylalanine
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :564.3±45.0 °C(Predicted)
Density :1.224
storage temp. :Inert atmosphere,Store in freezer, under -20°C
pka :3.81±0.11(Predicted)
form :liquid
color :pale yellow
InChIKey :FNCSRFHDUZYOCR-NRFANRHFSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.

Description

Olefinic alpha-methyl amino acid for peptide stapling. Upon incorporation of this amino acid into a peptide, along with another of the same or derivative with a different length of the olefinic side chain, the two can be ′stapled′ via a ring closing metathesis reaction with Grubb′s catalyst (product # 579726). The resulting stapled peptide macrocycle has been shown to stabilize the alpha-helical structure of peptides, which can lead to favorable biological characteristics such as increased proteolytic stability and cellular uptake.

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