3-AP
|
- ₹9277.03 - ₹37530.28
- Product name: 3-AP
- CAS: 143621-35-6
- MF: C7H9N5S
- MW: 195.24
- EINECS:
- MDL Number:MFCD00924747
- Synonyms:3-Apct;C078157;Pan 811;Pan811;Pan-811;Triapine;2-((3-AMinopyridin-2-yl)Methylene)hydrazinecarbothioaMide;NSC 663249
4 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- 100MG
- ManufacturerTCI Chemicals (India)
- Product numberA3132
- Product description2-[(3-Aminopyridin-2-yl)methylene]hydrazinecarbothioamide
- Packaging25MG
- Price₹9800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberA3132
- Product description2-[(3-Aminopyridin-2-yl)methylene]hydrazinecarbothioamide
- Packaging100MG
- Price₹28300
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0568
- Product description3-AP ≥98% (HPLC)
- Packaging5MG
- Price₹9277.03
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0568
- Product description3-AP ≥98% (HPLC)
- Packaging25MG
- Price₹37530.28
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | A3132 | 2-[(3-Aminopyridin-2-yl)methylene]hydrazinecarbothioamide | 25MG | ₹9800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A3132 | 2-[(3-Aminopyridin-2-yl)methylene]hydrazinecarbothioamide | 100MG | ₹28300 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | SML0568 | 3-AP ≥98% (HPLC) | 5MG | ₹9277.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0568 | 3-AP ≥98% (HPLC) | 25MG | ₹37530.28 | 2022-06-14 | Buy |
Properties
Melting point :234 °C
Boiling point :436.0±55.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10Meq/mL, clear
pka :10.93±0.70(Predicted)
form :powder
color :white to light brown
CAS DataBase Reference :143621-35-6
Boiling point :436.0±55.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10Meq/mL, clear
pka :10.93±0.70(Predicted)
form :powder
color :white to light brown
CAS DataBase Reference :143621-35-6
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair. It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species. Furthermore, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.More related product prices
Related product price
- 143621-35-6
₹9277.03-37530.28
