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2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester

2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester Structure
  • ₹11506.98 - ₹46374.3
  • Product name: 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester
  • CAS: 305834-79-1
  • MF: C17H17ClN2O5
  • MW: 364.78
  • EINECS:
  • MDL Number:MFCD02681303
  • Synonyms:2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester;2-Amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester;Akt Activator II, SC79 ;Akt Activator II;SC79;SC 79;AKT ACTIVATOR II;4H-1-Benzopyran-4-acetic acid, 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-, ethyl ester;SC79;SC 79;Akt Activator II, SC79 - CAS 305834-79-1 - Calbiochem
3 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0749
  • Product descriptionSC79 ≥97% (NMR)
  • Packaging5MG
  • Price₹11506.98
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number123871
  • Product descriptionAkt Activator II, SC79 - CAS 305834-79-1 - Calbiochem Akt Activator II, SC79, CAS 305834-79-1, is a cell-permeable compound that interacts with Akt PH domain PIP3 binding pocket and makes it more suscepti
  • Packaging25MG
  • Price₹20000
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0749
  • Product descriptionSC79 ≥97% (NMR)
  • Packaging25MG
  • Price₹46374.3
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0749 SC79 ≥97% (NMR) 5MG ₹11506.98 2022-06-14 Buy
Sigma-Aldrich(India) 123871 Akt Activator II, SC79 - CAS 305834-79-1 - Calbiochem Akt Activator II, SC79, CAS 305834-79-1, is a cell-permeable compound that interacts with Akt PH domain PIP3 binding pocket and makes it more suscepti 25MG ₹20000 2022-06-14 Buy
Sigma-Aldrich(India) SML0749 SC79 ≥97% (NMR) 25MG ₹46374.3 2022-06-14 Buy

Properties

Boiling point :524.8±50.0 °C(Predicted)
Density :1.340±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
pka :3.03±0.40(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Description

SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation, in the cytosol, by upstream kinases. For example, both Thr308 and Ser473 on Akt are phosphorylated in serum starved HeLa cells treated for 1 hour with insulin growth factor and SC-79 (4 μg/ml). SC-79 permits phosphorylation and activation of all isoforms of Akt, it is active in multiple cell types, and works in both receptor tyrosine kinase- and G protein-coupled receptor-mediated signaling. SC-79 has been used to elucidate the role of Akt signaling in neuronal survival, glucose-mediated apoptosis in podocytes, and miR-221-regulated cancer cell proliferation.

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