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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Nuclear transcription factor (NF-κB) >IκB / IKK inhibitors >SC-514

SC-514

SC-514 Structure
  • ₹8584.23 - ₹34737.43
  • Product name: SC-514
  • CAS: 354812-17-2
  • MF: C9H8N2OS2
  • MW: 224.3
  • EINECS:
  • MDL Number:MFCD00206459
  • Synonyms:SC-514, >=98%;3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide;SC-514;GK 01140;IKK-2 Inhibitor, SC-514 ;4-Amino-[2',3'-bithiophene]-5-carboxamide;SC-514;5-(Thien-3-yl)-3-aminothiophene-2-carboxamide;GK 01140
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0557
  • Product descriptionSC-514 ≥97% (HPLC)
  • Packaging5MG
  • Price₹8584.23
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number401479
  • Product descriptionIKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem The IKK-2 Inhibitor, SC-514, also referenced under CAS 354812-17-2, controls the biological activity of IKK-2. This small molecule/inhibitor is primar
  • Packaging1MG
  • Price₹14260
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0557
  • Product descriptionSC-514 ≥97% (HPLC)
  • Packaging25MG
  • Price₹34737.43
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0557 SC-514 ≥97% (HPLC) 5MG ₹8584.23 2022-06-14 Buy
Sigma-Aldrich(India) 401479 IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem The IKK-2 Inhibitor, SC-514, also referenced under CAS 354812-17-2, controls the biological activity of IKK-2. This small molecule/inhibitor is primar 1MG ₹14260 2022-06-14 Buy
Sigma-Aldrich(India) SML0557 SC-514 ≥97% (HPLC) 25MG ₹34737.43 2022-06-14 Buy

Properties

Melting point :209-211°C
Boiling point :399.2±42.0 °C(Predicted)
Density :1.450±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :15.63±0.50(Predicted)
form :powder
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SC-514 is a selective and reversible inhibitor of IKKβ (IKK-2) (IC50 = 3-12 μM) that displays >10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. This compound attenuates NF-κB-induced gene expression of IL-6, IL-8 and Cox-2 (IC50 = 20, 20, and 8 μM, respectively). Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection.

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