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N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE

N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE Structure
  • ₹16670.01 - ₹51390
  • Product name: N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE
  • CAS: 405098-33-1
  • MF: C30H37ClN2O2
  • MW: 493.08
  • EINECS:
  • MDL Number:MFCD26142284
  • Synonyms:N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE;N-{[4-(diMethylaMino)phenyl]Methyl}-7-Methoxy-N-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxaMide hydrochloride;W-54011;C5a Receptor Antagonist, W-54011;CS-2062;chemotaxis,inhibit,orally,W-54011,mobilization,anaphylatoxin,ROS,Reactive Oxygen Species,Ca2+,C5a,neutrophils,Inhibitor,Complement System,W54011,inflammatory,W 54011;N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE
Price4 Properties Safety Information Description
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Brand

  • Sigma-Aldrich
  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • ManufacturerSigma-Aldrich
  • Product number234415
  • Product descriptionC5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem The C5a Receptor Antagonist, W-54011, also referenced under CAS 405098-33-1, controls the biological activity of C5a Receptor.
  • Packaging1MG
  • Price₹16670.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number234415
  • Product descriptionC5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem The C5a Receptor Antagonist, W-54011, also referenced under CAS 405098-33-1, controls the biological activity of C5a Receptor.
  • Packaging5MG
  • Price₹51390
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number234415
  • Product descriptionC5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem The C5a Receptor Antagonist, W-54011, also referenced under CAS 405098-33-1, controls the biological activity of C5a Receptor.
  • Packaging1MG
  • Price₹16670.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number234415
  • Product descriptionC5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem The C5a Receptor Antagonist, W-54011, also referenced under CAS 405098-33-1, controls the biological activity of C5a Receptor.
  • Packaging5MG
  • Price₹51390
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich 234415 C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem The C5a Receptor Antagonist, W-54011, also referenced under CAS 405098-33-1, controls the biological activity of C5a Receptor. 1MG ₹16670.01 2022-06-14 Buy
Sigma-Aldrich 234415 C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem The C5a Receptor Antagonist, W-54011, also referenced under CAS 405098-33-1, controls the biological activity of C5a Receptor. 5MG ₹51390 2022-06-14 Buy
Sigma-Aldrich(India) 234415 C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem The C5a Receptor Antagonist, W-54011, also referenced under CAS 405098-33-1, controls the biological activity of C5a Receptor. 1MG ₹16670.01 2022-06-14 Buy
Sigma-Aldrich(India) 234415 C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem The C5a Receptor Antagonist, W-54011, also referenced under CAS 405098-33-1, controls the biological activity of C5a Receptor. 5MG ₹51390 2022-06-14 Buy

Properties

storage temp. :Store at -20°C
solubility :DMF: 30 mg/mL; DMSO: 30 mg/mL; Ethanol: 3 mg/mL
form :White powder solid.
color :White to light yellow
Stability :Hygroscopic

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

C5a Receptor Antagonist, W-54011 is a potent, specific, and orally active CD88 (C5a receptor) antagonist. Shown to inhibit the binding of 125I-rhC5a to human neutrophils with a Ki of 2.2 nM, as well as C5a-induced intracellular Ca2+-mobilization, chemotaxis and reactive oxygen species (ROS) generation (IC50 = 3.1 nM, 2.7 nM and 1.6 nM, respectively) with no agonist activity up to 10 μM. Shown to prevent C5a-induced neutrophenia in gerbils (100 μg/kg i.v. or 3-30 mg/kg orally).

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