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2,4-DIETHYLPYRIDINE DICARBOXYLATE

2,4-DIETHYLPYRIDINE DICARBOXYLATE Structure
  • ₹4200 - ₹9700
  • Product name: 2,4-DIETHYLPYRIDINE DICARBOXYLATE
  • CAS: 41438-38-4
  • MF: C11H13NO4
  • MW: 223.23
  • EINECS:680-341-5
  • MDL Number:MFCD00152168
  • Synonyms:DIETHYL 2,4-PYRIDINECARBOXYLATE;Diethyl 2,4-pyridinedicarboxylate;2,4-Pyridinedicarboxylic acid, diethyl ester Pyridine-2,4-Dicarboxylic Acid Diethyl Ester;2,4-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER;2,4-DPD;2,4-DIETHYLPYRIDINE DICARBOXYLATE;2,4-Pyridinedicarboxylic;2,4-pyridinedicarboxylicacid,ethylester
2 prices
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Brand

  • TCI Chemicals (India)

Package

  • 200MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberD5518
  • Product descriptionDiethyl 2,4-Pyridinedicarboxylate min. 97.0 %
  • Packaging200MG
  • Price₹4200
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberD5518
  • Product descriptionDiethyl 2,4-Pyridinedicarboxylate min. 97.0 %
  • Packaging1G
  • Price₹9700
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) D5518 Diethyl 2,4-Pyridinedicarboxylate min. 97.0 % 200MG ₹4200 2022-05-26 Buy
TCI Chemicals (India) D5518 Diethyl 2,4-Pyridinedicarboxylate min. 97.0 % 1G ₹9700 2022-05-26 Buy

Properties

Melting point :31 °C
Boiling point :330.9±22.0 °C(Predicted)
Density :1.165±0.06 g/cm3(Predicted)
vapor pressure :0.022Pa at 25℃
storage temp. :2-8°C
solubility :≤50mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide
pka :-0.69±0.10(Predicted)
form :Crystalline
color :White to Almost white
LogP :1.92 at 20℃ and pH7.82
Surface tension :56.3mN/m at 1g/L and 19.7℃
CAS DataBase Reference :41438-38-4

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH). 2,4-DPD is a cell permeable, competitive inhibitor of HIF-PH. 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor α-keto glutarate, with effective concentrations in the low μM range. 2,4-DPD is therefore expected to act as a pro-angiogenic compound, via the HIF-1α system.

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