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ChemicalBook > Product Catalogue >API >Digestive system drugs >Antacid and Mucosal protective Drugs >5-Aminosalicylic acid

5-Aminosalicylic acid

5-Aminosalicylic acid Structure
  • ₹765 - ₹94296.58
  • Product name: 5-Aminosalicylic acid
  • CAS: 89-57-6
  • MF: C7H7NO3
  • MW: 153.14
  • EINECS:201-919-1
  • MDL Number:MFCD00007877
  • Synonyms:5-AMINOSALICYLIC ACID;5-AS;LABOTEST-BB LT00134704;IFLAB-BB F1918-0003;BENZOIC ACID, 5-AMINO-2-HYDROXY-;M-AMINOSALICYLIC ACID;5-Amino-2-hydroxybenzoic acid~Mesalamine;5-Aminosalicylic acid;5-Amino-2-hydroxybenzoic acid; 5-ASA
Price11 Properties Safety Information Description
11 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)
  • TCI Chemicals (India)
  • ottokemi

Package

  • 1G
  • 5G
  • 25gm
  • 25G
  • 100G
  • 100gm
  • 500G
  • ManufacturerSigma-Aldrich(India)
  • Product numberA79809
  • Product description5-Aminosalicylic acid 95%
  • Packaging5G
  • Price₹2089.23
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA79809
  • Product description5-Aminosalicylic acid 95%
  • Packaging100G
  • Price₹7729.05
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1060
  • Product descriptionMesalamine Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹8465.15
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA3537
  • Product description5-Aminosalicylic acid ≥99%
  • Packaging25G
  • Price₹31035.28
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA3537
  • Product description5-Aminosalicylic acid ≥99%
  • Packaging100G
  • Price₹94296.58
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberA0317
  • Product description5-Aminosalicylic Acid
  • Packaging500G
  • Price₹15200
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberA2291
  • Product description5-Aminosalicylic Acid [for Biochemical Research]
  • Packaging25G
  • Price₹7600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberA0317
  • Product description5-Aminosalicylic Acid
  • Packaging25G
  • Price₹2500
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberA2291
  • Product description5-Aminosalicylic Acid [for Biochemical Research]
  • Packaging5G
  • Price₹2300
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number A 2016
  • Product description5-Aminosalicylic acid 98%
  • Packaging100gm
  • Price₹2142
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number A 2016
  • Product description5-Aminosalicylic acid 98%
  • Packaging25gm
  • Price₹765
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) A79809 5-Aminosalicylic acid 95% 5G ₹2089.23 2022-06-14 Buy
Sigma-Aldrich(India) A79809 5-Aminosalicylic acid 95% 100G ₹7729.05 2022-06-14 Buy
Sigma-Aldrich(India) PHR1060 Mesalamine Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹8465.15 2022-06-14 Buy
Sigma-Aldrich(India) A3537 5-Aminosalicylic acid ≥99% 25G ₹31035.28 2022-06-14 Buy
Sigma-Aldrich(India) A3537 5-Aminosalicylic acid ≥99% 100G ₹94296.58 2022-06-14 Buy
TCI Chemicals (India) A0317 5-Aminosalicylic Acid 500G ₹15200 2022-05-26 Buy
TCI Chemicals (India) A2291 5-Aminosalicylic Acid [for Biochemical Research] 25G ₹7600 2022-05-26 Buy
TCI Chemicals (India) A0317 5-Aminosalicylic Acid 25G ₹2500 2022-05-26 Buy
TCI Chemicals (India) A2291 5-Aminosalicylic Acid [for Biochemical Research] 5G ₹2300 2022-05-26 Buy
ottokemi A 2016 5-Aminosalicylic acid 98% 100gm ₹2142 2022-05-26 Buy
ottokemi A 2016 5-Aminosalicylic acid 98% 25gm ₹765 2022-05-26 Buy

Properties

Melting point :275-280 °C (dec.) (lit.)
Boiling point :276.03°C (rough estimate)
Density :1.3585 (rough estimate)
vapor pressure :0Pa at 25℃
refractive index :1.5500 (estimate)
Flash point :279-281°C
storage temp. :2-8°C
solubility :Soluble in dimethyl sulfoxide.
pka :2.74, 5.84(at 25℃)
form :tablets
color :off-white to gray
PH :4.0-4.1 (0.8g/l, H2O, 20℃)
PH Range :Non-B uorescence (3.1) to light green B uorescence (4.4)
Water Solubility :<0.1 g/100 mL at 21 ºC
Decomposition :279-281 ºC
Merck :14,5904
BRN :2090421
BCS Class :4
Stability :Stable. Incompatible with acids, acid anhydrides, acid chlorides, chloroformates, strong oxidizing agents.
Major Application :Detergent, hair dyes, prevention of colorectal cancer, treating inflammatory bowel disease, autoimmune disorders, gastrointestinal inflammation, chemokine-mediated diseases, mucosal tissue disorder, sleep disorders, rectoanal tenesmus, ulcerative colitis
InChIKey :KBOPZPXVLCULAV-UHFFFAOYSA-N
LogP :0.98 at 25℃
CAS DataBase Reference :89-57-6(CAS DataBase Reference)
NIST Chemistry Reference :Mesalamine(89-57-6)
EPA Substance Registry System :Benzoic acid, 5-amino-2-hydroxy- (89-57-6)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

5-Aminosalicylic acid (5-ASA) is a metabolite and potential pharmacologically active component of sulphasalazine, a drug used in the treatment of Crohn’s disease and ulcerative colitis. However, the mechanism by which this drug works has not been established. In whole blood assays, 5-ASA proves to be a weak, non-selective inhibitor of both COX-1 and COX-2 with IC50 values of 410 and 61 μM, respectively. In ionophore-stimulated colonic mucosal cells, 1 mM 5-ASA does not inhibit prostaglandin E2 (PGE2) production, but does reduce leukotriene B4 (LTB4) synthesis approx. 50%. In ionophore-stimulated human leukocytes, 400 μM 5-ASA reduces LTB4 production approximately 20%. 5-ASA does not inhibit 15-hydroxy PGDH at concentrations up to 50 μM.

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