6-THIO-2'-DEOXYGUANOSINE
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- Product name: 6-THIO-2'-DEOXYGUANOSINE
- CAS: 789-61-7
- MF: C10H13N5O3S
- MW: 283.31
- EINECS:
- MDL Number:MFCD00672275
- Synonyms:2’-deoxy-6-thio-guanosin ;2’-deoxythioguanosine ;2-amino-9-(2-deoxy-beta-d-erythro-pentofuranosyl)-9h-purine-6(1h)-thion ;beta-2’-deoxythioguanosine ;beta-thioguaninedeoxyriboside ;nci-c01581 ;tgdr ;BETA-THIOGUANIDINEDEOXYRIBOSIDE
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Properties
Melting point :190-192 °C
Boiling point :709.1±70.0 °C(Predicted)
Density :2.02±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), DMF (Slightly), Methanol (Slightly, Heated), Water (Very Slightly)
form :Solid
pka :6.81±0.20(Predicted)
color :Yellow to Brown
Boiling point :709.1±70.0 °C(Predicted)
Density :2.02±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), DMF (Slightly), Methanol (Slightly, Heated), Water (Very Slightly)
form :Solid
pka :6.81±0.20(Predicted)
color :Yellow to Brown
Safety Information
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Description
6-thio-2′-Deoxyguanosine (6-thio-dG) is a nucleoside analog that is incorporated into de novo-synthesized telomeres by telomerase. This induces telomerase dysfunction resulting in telomeric DNA damage and rapid cell death. This process occurs in cells expressing telomerase but not in telomerase-negative cells. DNA containing 6-thio-dG inhibits the function of RNase H, preventing the cleavage of DNA-RNA heteroduplexes. In mouse xenograft studies using A549 lung cancer cells, 6-thio-dG causes a decrease in tumor growth rate associated with telomere dysfunction.More related product prices
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