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ChemicalBook > Product Catalogue >API >Hormones and the Endocrine System >Adrenal corticosteroids >fluocinolone16,17-acetonide

fluocinolone16,17-acetonide

fluocinolone16,17-acetonide Structure
  • ₹8486.8 - ₹52945.08
  • Product name: fluocinolone16,17-acetonide
  • CAS: 67-73-2
  • MF: C24H30F2O6
  • MW: 452.49
  • EINECS:200-668-5
  • MDL Number:MFCD00010525
  • Synonyms:(6-alpha,11-beta,16-alpha)-idene)bis(oxy)) ;(6alpha,11beta,16alpha)-idene)bis(oxy)) ;20-dione,6,9-difluoro-11,12-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-,(6-alpha,11-bpregna-4-diene-3 ;6alpha,9alpha-difluoro-16alpha-hydroxyprednisolone16,17-acetonide ;fluocinolone16,17-acetonide ;Fluocinoloneacetate ;fluovitif ;jellin
3 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 100MG
  • 500MG
  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product numberF8880
  • Product descriptionFluocinolone acetonide analytical standard
  • Packaging100MG
  • Price₹8486.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1397
  • Product descriptionFluocinolone Acetonide Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging500MG
  • Price₹10002.3
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberF8880
  • Product descriptionFluocinolone acetonide analytical standard
  • Packaging1G
  • Price₹52945.08
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) F8880 Fluocinolone acetonide analytical standard 100MG ₹8486.8 2022-06-14 Buy
Sigma-Aldrich(India) PHR1397 Fluocinolone Acetonide Pharmaceutical Secondary Standard; Certified Reference Material 500MG ₹10002.3 2022-06-14 Buy
Sigma-Aldrich(India) F8880 Fluocinolone acetonide analytical standard 1G ₹52945.08 2022-06-14 Buy

Properties

Melting point :267-269 °C(lit.)
Boiling point :578.5±50.0 °C(Predicted)
alpha :D +95° (chloroform)
Density :1.1826 (estimate)
refractive index :103 ° (C=1, MeOH)
storage temp. :Refrigerator
solubility :Practically insoluble in water, soluble in acetone and in ethanol
form :Solid
pka :12.78±0.70(Predicted)
color :White to Off-White
Water Solubility :Soluble in water (partly), DMSO, alcohol, chloroform and methanol.
Merck :14,4150
InChIKey :FEBLZLNTKCEFIT-VSXGLTOVSA-N
CAS DataBase Reference :67-73-2(CAS DataBase Reference)
EPA Substance Registry System :Fluocinolone acetonide (67-73-2)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Fluocinolone acetonide is primarily used in dermatology to reduce skin inflammation and relieve itching. It acts as an inhibitor of tumor cells and it can regulate lipid metabolism by modulating gene expression. It can also inhibit the expression of VEGF (vascular endothelial growth factor) in the retinal pigment epithelial cell line due to its high glucocorticoid receptor affinity. Furthermore, it can inhibit TNF-α angiogenesis.

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