7-Dehydrocholesterol
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- ₹8227
- Product name: 7-Dehydrocholesterol
- CAS: 434-16-2
- MF: C27H44O
- MW: 384.64
- EINECS:207-100-5
- MDL Number:MFCD00003624
- Synonyms:(3)-7-Dehydrochlesterol ;(3beta)-Cholesta-5,7-dien-3-ol;(3-beta)-cholesta-7-dien-3-ol ;(3beta)-cholesta-7-dien-3-ol ;3-Hydroxycholesta-5,7-diene ;Cholesta-5,7-dien-3-ol, (3beta)-;Cholesterol, 7-dehydro-;Dehydrocholesterin
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5G
- ManufacturerSigma-Aldrich(India)
- Product number30800
- Product description7-Dehydrocholesterol ≥95.0% (HPLC)
- Packaging5G
- Price₹8227
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 30800 | 7-Dehydrocholesterol ≥95.0% (HPLC) | 5G | ₹8227 | 2022-06-14 | Buy |
Properties
Melting point :148-152 °C(lit.)
alpha :-116 º (C=1, CHCL3)
Boiling point :451.27°C (rough estimate)
Density :0.9717 (rough estimate)
refractive index :1.5100 (estimate)
storage temp. :-20°C
solubility :Chloroform (Sparingly), DMSO (Slightly, Heated, Sonicated), Ethyl Acetate (Slightly)
form :Solid
pka :14.91±0.70(Predicted)
color :White to Yellow
optical activity :[α]20/D -115±8°, c = 1% in chloroform
Water Solubility :Insoluble
Merck :13,2887
BRN :2224615
Stability :Light Sensitive
InChIKey :UCTLRSWJYQTBFZ-DDPQNLDTSA-N
LogP :9.460 (est)
CAS DataBase Reference :434-16-2(CAS DataBase Reference)
NIST Chemistry Reference :Cholesta-5,7-dien-3-ol, (3«beta»)-(434-16-2)
EPA Substance Registry System :Cholesta-5,7-dien-3-ol, (3.beta.)- (434-16-2)
alpha :-116 º (C=1, CHCL3)
Boiling point :451.27°C (rough estimate)
Density :0.9717 (rough estimate)
refractive index :1.5100 (estimate)
storage temp. :-20°C
solubility :Chloroform (Sparingly), DMSO (Slightly, Heated, Sonicated), Ethyl Acetate (Slightly)
form :Solid
pka :14.91±0.70(Predicted)
color :White to Yellow
optical activity :[α]20/D -115±8°, c = 1% in chloroform
Water Solubility :Insoluble
Merck :13,2887
BRN :2224615
Stability :Light Sensitive
InChIKey :UCTLRSWJYQTBFZ-DDPQNLDTSA-N
LogP :9.460 (est)
CAS DataBase Reference :434-16-2(CAS DataBase Reference)
NIST Chemistry Reference :Cholesta-5,7-dien-3-ol, (3«beta»)-(434-16-2)
EPA Substance Registry System :Cholesta-5,7-dien-3-ol, (3.beta.)- (434-16-2)
Safety Information
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Description
7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3β-hydroxysterol-Δ7-reductase (DHCR7) in the last step of cholesterol biosynthesis from squalene. Mutations in the gene encoding DHCR7 lead to increased levels of 7-DHC and the neurodevelopmental syndrome Smith-Lemli-Opitz syndrome (SLOS). 7-DHC is elevated in rats treated with the DHCR7 inhibitor AY9944, an animal model of SLOS. 7-DHC is subject to free radical oxidation (autoxidation), giving rise to several oxysterols which contribute to pathogenesis. Serum levels of 7-DHC, largely derived from the liver, are approximately 0.3 μM in healthy individuals. In the skin, photolysis of 7-DHC by ultraviolet light produces vitamin D3 .More related product prices
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