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2-(4-Isopropylpheny)-4H-chroMen-4-one

2-(4-Isopropylpheny)-4H-chroMen-4-one Structure
  • ₹0
  • Product name: 2-(4-Isopropylpheny)-4H-chroMen-4-one
  • CAS: 92831-11-3
  • MF: C18H16O2
  • MW: 264.32
  • EINECS:
  • MDL Number:MFCD00829158
  • Synonyms:MN-64;2-(4-Propan-2-ylphenyl)chromen-4-one;2-(4-Isopropylpheny)-4H-chroMen-4-one;2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-[4-(1-methylethyl)phenyl]-;MN64, >98%;2-(4-Isopropyl-phenyl)-chromen-4-one;MN64; MN 64
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :63-64 °C(Solv: ethanol (64-17-5))
Boiling point :389.8±42.0 °C(Predicted)
Density :1.152±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Tankyrases (TNKS) are poly-ADP-ribosyltransferases, which cleave NAD+ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in a process known as poly(ADP-ribosyl)ation. MN-64 is a potent inhibitor of TNKS1 and TNKS2 (IC50s = 6 and 72 nM, respectively). It is ineffective against several poly(ADP-ribosyl) polymerases (IC50 > 19 μM). Through its effects on TNKS, MN-64 inhibits signaling along the Wnt/β-catenin pathway in a cell-based reporter assay.

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