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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Epigenetics >Histone Methyltransferase Inhibitors >MM-102

MM-102

MM-102 Structure
  • ₹0
  • Product name: MM-102
  • CAS: 1417329-24-8
  • MF: C35H49F2N7O4
  • MW: 669.8
  • EINECS:-0
  • MDL Number:MFCD28015099
  • Synonyms:MM-102;Cyclopentanecarboxamide, 1-[[(2S)-5-[(aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-;HMTase Inhibitor IX;1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]cyclopentanecarboxamide];CS-2007;HMTASE INHIBITOR IX;MM102;MM 102;MM-102;MM-102 TFA Salt;MM-102 USP/EP/BP
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Density :1.26±0.1 g/cm3(Predicted)
storage temp. :Store at -20° C
solubility :insoluble in H2O; ≥22.6 mg/mL in EtOH; ≥67 mg/mL in DMSO
form :Powder
pka :12.90±0.20(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones. It serves as a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3 at lysine 4 to upregulate transcription. MM-102 is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM). It has been shown to block MLL1 methyltransferase activity, reducing the expression of HoxA9 and Meis-1 genes, which are both critical MLL1 target genes in MLL1 fusion protein-mediated leukemogenesis. MM-102 can also inhibit cell growth and induce apoptosis in leukemia cells harboring MLL1 fusion proteins.

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Suppliers and manufacturers

Shaanxi Dideu Medichem Co. Ltd
MM-102
₹0.00 /1g
MM-102 CAS:1417329-24-8
CLEARSYNTH LABS LTD.
ATK CHEMICAL COMPANY LIMITED
Career Henan Chemica Co
Dideu Industries Group Limited
BOC Sciences
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.
TargetMol Chemicals Inc.