AT7867
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- ₹0
- Product name: AT7867
- CAS: 857531-00-1
- MF: C20H20ClN3
- MW: 337.85
- EINECS:-0
- MDL Number:MFCD18384971
- Synonyms:AT7867;Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-;4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine;AT-7867(AT7867);4-(4-(1H-pyrazol-4-yl)phenyl)-4-(4-chlorophenyl)piperidine;4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine AT 7867;Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]- 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine;CS-1865
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Properties
Density :1.214
storage temp. :Store at -20°C
solubility :≥16.9 mg/mL in DMSO; ≥4.38 mg/mL in EtOH with ultrasonic; ≥45 mg/mL in H2O
form :solid
color :White to off-white
storage temp. :Store at -20°C
solubility :≥16.9 mg/mL in DMSO; ≥4.38 mg/mL in EtOH with ultrasonic; ≥45 mg/mL in H2O
form :solid
color :White to off-white
Safety Information
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Description
AT7867 is a potent and orally bioavailable inhibitor of Akt isoforms Akt1, 2, and 3 (IC50s = 32, 17, and 47 nM, respectively). It also inhibits p70S6 kinase and PKA (IC50s = 85 and 20 nM, respectively), but is without effect against a panel of other kinases. AT7867 inhibits growth and induces apoptosis in a variety of cancer cell lines in vitro and suppresses tumor growth of PTEN-deficient xenografts in mice.Related product price
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