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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >S6 Kinase Inhibitors >PF-4708671

PF-4708671

PF-4708671 Structure
  • ₹14115.8 - ₹56852.9
  • Product name: PF-4708671
  • CAS: 1255517-76-0
  • MF: C19H21F3N6
  • MW: 390.41
  • EINECS:
  • MDL Number:MFCD18086922
  • Synonyms:2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole;PF 4708671;PF4708671/PF-4708671;2-[[4-(5-ethyl-4-pyriMidinyl)-1-piperazinyl]Methyl]-6-(trifluoroMethyl)-1H-benziMidazole;PF-04708671;1H-Benzimidazole, 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-;2-[[4-(5-Ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole PF-4708671;2-[[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-6-(trifluoromethyl)-1H-benzimidazole
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0143
  • Product descriptionPF-4708671 ≥98% (HPLC)
  • Packaging5MG
  • Price₹14115.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0143
  • Product descriptionPF-4708671 ≥98% (HPLC)
  • Packaging25MG
  • Price₹56852.9
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0143 PF-4708671 ≥98% (HPLC) 5MG ₹14115.8 2022-06-14 Buy
Sigma-Aldrich(India) PZ0143 PF-4708671 ≥98% (HPLC) 25MG ₹56852.9 2022-06-14 Buy

Properties

Boiling point :572.8±50.0 °C(Predicted)
Density :1.348±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: ≥20mg/mL
form :powder
pka :10.20±0.10(Predicted)
color :off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

P70 ribosomal S6 kinase (S6K1) is a serine/threonine kinase which is activated by insulin and growth factors through PI3K and mTORC1 signaling pathways. PF-04708671 is a specific, cell-permeable inhibitor of S6K1 (IC50 = 160 nM). It does not inhibit S6K2, MSK, or RSK, or many other unrelated kinases, under conditions in which it inhibits S6K1 activity. It is useful in evaluating the role of S6K1 and, indirectly, mTORC1, in cell signaling.

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