AVN-944
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- Product name: AVN-944
- CAS: 297730-17-7
- MF: C25H27N5O5
- MW: 477.51
- EINECS:
- MDL Number:
- Synonyms:VX 944;VX944;VX-944;AVN944 (VX-944);(R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate;VX 944; AVN-944;;CS-1604;[(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate
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Properties
Boiling point :597.4±50.0 °C(Predicted)
Density :1.277±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.52(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);62.83(Max Conc. mM) form :A crystalline solid
pka :11.38±0.46(Predicted)
color :White to off-white
Density :1.277±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.52(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);62.83(Max Conc. mM) form :A crystalline solid
pka :11.38±0.46(Predicted)
color :White to off-white
Safety Information
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Description
AVN944 is a selective, noncompetitive inhibitor of inosine-5''-monophosphate dehydrogenase (IMPDH; Ki = 6-10 nM for both human IMPDH isoforms), a rate-limiting enzyme involved in the de novo synthesis of purine nucleotides. Inhibition of IMPDH results in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN944 has been shown to inhibit the proliferation of multiple myeloma cells in vitro by inducing caspase-independent apoptosis. It is also reported to have antitumor properties in androgen-sensitive and androgen-independent prostate cancer cells in vitro.Related product price
Suppliers and manufacturers
TargetMol Chemicals Inc.
Zhejiang J&C Biological Technology Co.,Limited
LEAP CHEM CO., LTD.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific
Amadis Chemical Company Limited
Angel Pharmatech, Ltd.
Chuzhou KeMail Chemical Technology Co., Ltd
Shanghai YuanQi Biotechnology Co., Ltd.
![[(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate](https://img.chemicalbook.com/ProductImageEN/2020-1/small/000a41f5-0222-4479-966f-aed4abf409ce.png){kind=small}