VX-745
|
- ₹11233.2 - ₹45177
- Product name: VX-745
- CAS: 209410-46-8
- MF: C19H9Cl2F2N3OS
- MW: 436.26
- EINECS:
- MDL Number:MFCD09834070
- Synonyms:6H-PYRIMIDO[1,6-B]PYRIDAZIN-6-ONE, 5-(2,6-DICHLOROPHENYL)-2-[(2,4-DIFLUOROPHENYL)THIO]- (9CI);6H-PYRIMIDO[1,6-B]PYRIDAZIN-6-ONE, 5-(2,6-DICHLOROPHENYL)-2-[(2,4-DIFLUOROPHENYL)THIO]-;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylsulfanyl)-6H-pyriMido[3,4-b]pyridazin-6-one;VX-745(VX 745);5-(2,6-Dichloro-phenyl)-2-(2,4-difluoro-phenylsulfanyl)-1,7,8a-triaza-naphthalen-6-one;5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyridazino[6,1-f]pyrimidin-6-one VX-745
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1638
- Product descriptionVX-745 ≥98% (HPLC)
- Packaging5MG
- Price₹11233.2
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1638
- Product descriptionVX-745 ≥98% (HPLC)
- Packaging25MG
- Price₹45177
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1638 | VX-745 ≥98% (HPLC) | 5MG | ₹11233.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1638 | VX-745 ≥98% (HPLC) | 25MG | ₹45177 | 2022-06-14 | Buy |
Properties
Melting point :261-264 °C
Boiling point :578.9±60.0 °C(Predicted)
Density :1.55±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥21.8 mg/mL in DMSO; insoluble in H2O; ≥2.1 mg/mL in EtOH with gentle warming and ultrasonic
form :powder
pka :-0.97±0.40(Predicted)
color :white to beige
Boiling point :578.9±60.0 °C(Predicted)
Density :1.55±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥21.8 mg/mL in DMSO; insoluble in H2O; ≥2.1 mg/mL in EtOH with gentle warming and ultrasonic
form :powder
pka :-0.97±0.40(Predicted)
color :white to beige
Safety Information
| Symbol(GHS): |
|
||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
p38α is a member of the mitogen-activated protein kinase (MAPK) family of serine/threonine protein kinases. It is widely expressed in endothelial, immune, and inflammatory cells and plays a central role in the regulation of proinflammatory cytokine production including TNF-α, IL-1β, and IL-6. VX-745 is a potent inhibitor of p38α MAPK (IC50 = 10 nM) with 20-fold selectivity over p38β and 1000-fold selectivity over closely related kinases, ERK1 and JNK1-3. It blocks IL-1β and TNF-α release in whole blood in vitro with IC50 values of 150 and 180 nM, respectively. VX-745 has been shown to demonstrate anti-inflammatory efficacy in an animal model of rheumatoid arthritis, but was discontinued in clinical trial due to adverse central nervous system effects.More related product prices
Thionyl chloride Triphenylphosphine 149-74-6 Dichlorodiphenylsilane Sulfadiazine 402957-28-2 Tozasertib Lumacaftor (VX-809) SGX-523 N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Enzalutamide (MDV3100) Tofacitinib citrate VX 702 896720-20-0 Pictilisib (GDC-0941) Carfilzomib Pimodivir VX-770Related product price
- Quinclorac
₹10121.38 - Thionyl chloride
₹1908 - Triphenylphosphine
₹747-110080