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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Transmembrane Transporters >CFTR modulator >Lumacaftor (VX-809)

Lumacaftor (VX-809)

Lumacaftor (VX-809) Structure
  • ₹0
  • Product name: Lumacaftor (VX-809)
  • CAS: 936727-05-8
  • MF: C24H18F2N2O5
  • MW: 452.41
  • EINECS:
  • MDL Number:MFCD16659051
  • Synonyms:3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxaMido)-3-Methylpyridin-2-yl)benzoic acid;VRT 826809;3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)be;VX 809, >=98%;VX-809 (LUMACAFTOR);VX 809;3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methylpyridin-2-yl]benzoic acid;3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl;VX-809 + IVACAFTOR
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :200-205oC
Boiling point :653.0±55.0 °C(Predicted)
Density :1.51
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly)
pka :3.95±0.10(Predicted)
form :Solid
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

VX 809 is used in the stabilization of the CFTR protein used in the treatment of cystic fibrosis.

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