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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Transmembrane Transporters >CFTR modulator >VX-661

VX-661

VX-661 Structure
  • ₹0
  • Product name: VX-661
  • CAS: 1152311-62-0
  • MF: C26H27F3N2O6
  • MW: 520.5
  • EINECS:
  • MDL Number:MFCD23106064
  • Synonyms:VX-661;VX-661/VX661;1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide;Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-;1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide VX661;(R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-;CS-956;VX661/Tezacaftor
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :610.8±55.0 °C(Predicted)
Density :1.49±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C , stored under nitrogen
solubility :≥21.8 mg/mL in DMSO; insoluble in EtOH; ≥24.3 mg/mL in H2O
form :solid
pka :13.99±0.20(Predicted)
color :White to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Tezacaftor (VX-661) is an oral medication for cystic fibrosis (CF) developed by Vertex Pharmaceuticals. In a combination therapy formulation called Symdeko (tezacaftor plus ivacaftor), it is approved in the U.S. and Canada for CF patients, ages 12 and older, who have two copies of the F508del mutation in the CFTR gene and one minimal function mutation. Symdeko is approved and marketed in the EU as Symkevi.Tezacaftor is not approved as a stand-alone treatment, but as part of a combination therapy.

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Suppliers and manufacturers

career henan chemical co
VX-661
₹8.00 /1kg
VX-661 CAS: 1152311-62-0
CLEARSYNTH LABS LTD. A.J Chemicals Pharmaffiliates Analytics and Synthetics P. Ltd Pharma Affiliates SynZeal Research Pvt Ltd
Hangzhou FandaChem Co.,Ltd.
BOC Sciences
Chongqing Chemdad Co., Ltd
ENBRIDGE PHARMTECH CO., LTD.