CFTRinh-172
|
- ₹16390 - ₹66974.28
- Product name: CFTRinh-172
- CAS: 307510-92-5
- MF: C18H10F3NO3S2
- MW: 409.4
- EINECS:
- MDL Number:MFCD06411408
- Synonyms:3-[(3-Trifluoromethyl)Phenyl]-5-[(4-Carboxyphenyl)Methylene]-2-Thioxo-4-Thiazolidinone 4-[(Z)-[4-Oxo-2-Sulfanylidene-3-[3-(Trifluoromethyl)Phenyl]-1,3-Thiazolidin-5-Ylidene]Methyl]Benzoic Acid;4-[[4-Oxo-2-Thioxo-3-[3-(Trifluoromethyl)Phenyl]Thiazolidin-;InSolution? CFTR Inhibitor-172 ;CFTR(INH)-172;CFTR INHIBITOR-172;5-[(4-CARBOXYPHENYL)METHYLENE]-2-THIOXO-3-[(3-TRIFLUOROMETHYL)PHENYL-4-THIAZOLIDINONE];3-[(3-TRIFLUOROMETHYL)PHENYL]-5-[(4-CARBOXYPHENYL)METHYLENE]-2-THIOXO-4-THIAZOLIDINONE;4-[4-OXO-2-THIOXO-3-(3TRIFLUOROMETHYL-PHENYL)-THIAZOLIDIN-5-YLIDENEMETHYL]-BENZOIC ACID (FOR R&D ONLY)
4 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberC2992
- Product descriptionCFTR(inh)-172 ≥98% (HPLC), powder
- Packaging25MG
- Price₹66974.28
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number219670
- Product descriptionCFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem CFTR Inhibitor-172, CAS 307510-92-5, is a cell-permeable, potent, reversible, rapid, and voltage-independent inhibitor of CFTR-mediated Cl- transport
- Packaging5MG
- Price₹20320
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberC2992
- Product descriptionCFTR(inh)-172 ≥98% (HPLC), powder
- Packaging5MG
- Price₹16562.25
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number219674
- Product descriptionInSolution CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem The InSolution CFTR Inhibitor-172, also referenced under CAS 307510-92-5, controls the biological activity of CFTR. This small molecule/inhibitor is p
- Packaging5MG
- Price₹16390
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C2992 | CFTR(inh)-172 ≥98% (HPLC), powder | 25MG | ₹66974.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 219670 | CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem CFTR Inhibitor-172, CAS 307510-92-5, is a cell-permeable, potent, reversible, rapid, and voltage-independent inhibitor of CFTR-mediated Cl- transport | 5MG | ₹20320 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C2992 | CFTR(inh)-172 ≥98% (HPLC), powder | 5MG | ₹16562.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 219674 | InSolution CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem The InSolution CFTR Inhibitor-172, also referenced under CAS 307510-92-5, controls the biological activity of CFTR. This small molecule/inhibitor is p | 5MG | ₹16390 | 2022-06-14 | Buy |
Properties
Melting point :181-183 °C
Boiling point :555.7±60.0 °C(Predicted)
Density :1.61±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
form :Yellow solid
pka :3.88±0.10(Predicted)
color :yellow
CAS DataBase Reference :307510-92-5
Boiling point :555.7±60.0 °C(Predicted)
Density :1.61±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
form :Yellow solid
pka :3.88±0.10(Predicted)
color :yellow
CAS DataBase Reference :307510-92-5
Safety Information
| Symbol(GHS): |
 
|
||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR Inhibitor-172 is a thiazolidinone that selectively blocks the CFTR channel (Ki = 300 nM) in a voltage-independent manner. It appears to directly modulate the gating of chloride at the channel and does not prevent elevation of cAMP or inhibit other pumps or channels. In mice, CFTR inhibitor-172 prevents cholera toxin-induced fluid secretion in the small intestine, when given by intraperitoneal injection. It slows cyst growth in animal models of polycystic kidney disease. As CFTR also modulates glutathione (GSH) efflux, CFTR inhibitor-172 can affect intracellular GSH concentration and reactive oxygen species balance.More related product prices
BEZ235 (NVP-BEZ235, Dactolisib) VX-661 BIRB 796 (Doramapimod) Lumacaftor (VX-809) VX-770 iOWH-032 4-Vinylbenzoic acidRelated product price
- BIRB 796 (Doramapimod)
₹14260 - VX-770
₹22390 - CFTRinh-172
₹16390-66974.28
Suppliers and manufacturers
CHEMSWORTH
ATK CHEMICAL COMPANY LIMITED
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Hangzhou MolCore BioPharmatech Co.,Ltd.
