VX-222
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- Product name: VX-222
- CAS: 1026785-59-0
- MF: C25H35NO4S
- MW: 445.61
- EINECS:-0
- MDL Number:MFCD18089858
- Synonyms:VX-222;5-(3,3-Dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-2-thiophenecarboxylic acid;VCH 222;VCH222;VCH-222;VX-222, VCH222;VX-222 (VCH-222, LoMibuvir);2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-
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Properties
Boiling point :640.5±55.0 °C(Predicted)
Density :1.21
storage temp. :Store at -20°C
solubility :≥44.6 mg/mL in DMSO; insoluble in H2O; ≥97.2 mg/mL in EtOH
form :solid
pka :3.67±0.10(Predicted)
Density :1.21
storage temp. :Store at -20°C
solubility :≥44.6 mg/mL in DMSO; insoluble in H2O; ≥97.2 mg/mL in EtOH
form :solid
pka :3.67±0.10(Predicted)
Safety Information
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Description
Lomibuvir is a non-nucleoside inhibitor of the RNA-directed RNA polymerase of hepatitis C virus (HCV; Ki = 17 nM) that inhibits primer-dependent RNA synthesis selectively over de novo RNA synthesis. It inhibits HCV replication in Huh7.5 cells expressing the 1b/Con1 HCV subgenomic replicon (EC50 = 5 nM).More related product prices
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