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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Endocrinology & Hormones >RAAS inhibitors >Aliskiren hemifumarate

Aliskiren hemifumarate

Aliskiren hemifumarate Structure
  • ₹6635.73 - ₹21465.98
  • Product name: Aliskiren hemifumarate
  • CAS: 173334-58-2
  • MF: C30H53N3O6
  • MW: 551.75832
  • EINECS:630-415-8
  • MDL Number:MFCD10566724
  • Synonyms:(2S,4S,5S,7S)-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hemifumarate;Aliskiren hemifumarate (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide hemifumarate;ALISKIREN FUMARATE;(2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide hemifumarate;Benzeneoctanamide, delta-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-gamma-hydroxy-4-methoxy-3-(3-methoxypropoxy)-alpha,zeta-bis(1-methylethyl)-, (alphas,gammas,deltas,zetas)-, (2E)-2-butenedioate (2:1) (salt);Aliskiren hemifumarate;Unii-C8A0p8G029;Aliskiren-D6 HeMifuMarate
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2077
  • Product descriptionAliskiren hemifumarate ≥95% (HPLC)
  • Packaging50MG
  • Price₹21465.98
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2077
  • Product descriptionAliskiren hemifumarate ≥95% (HPLC)
  • Packaging10MG
  • Price₹6635.73
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML2077 Aliskiren hemifumarate ≥95% (HPLC) 50MG ₹21465.98 2022-06-14 Buy
Sigma-Aldrich(India) SML2077 Aliskiren hemifumarate ≥95% (HPLC) 10MG ₹6635.73 2022-06-14 Buy

Properties

Melting point :72-75?C
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Methanol (Slightly), Water (Slightly)
form :Solid
color :White

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Aliskiren is a nonpeptide renin inhibitor (IC50 = 0.6 nM) that selectively binds to the S3 sub-pocket of renin, preventing the conversion of angiotensinogen to angiotensin I, thereby blocking eventual conversion to angiotensin II. Thus, by blocking renin, aliskiren was designed to prevent angiotensin II-mediated arterial vasoconstriction and aldosterone production. Aliskiren is orally bioavailable and, in combination with valsartan , was shown to reduce blood pressure in db/db mice.

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Suppliers and manufacturers

Hetero Drugs Limited Manus Aktteva JUBILANT GENERICS LTD A.J Chemicals CLEARSYNTH LABS LTD. Triveni chemicals Pharmaffiliates Analytics and Synthetics P. Ltd Mahalaxmi Chemi Pharm Sumsahi Kemicals Msn Laboratories Limited