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Alosetron hydrochloride

Alosetron hydrochloride Structure
  • ₹8075.45 - ₹31046.1
  • Product name: Alosetron hydrochloride
  • CAS: 122852-69-1
  • MF: C17H19ClN4O
  • MW: 330.81
  • EINECS:802-450-0
  • MDL Number:MFCD03453647
  • Synonyms:5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one hydrochloride;GR 68755C;2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1h-imidazol-4-yl)methyl]-1h-pyrido[4,3-b]indol-1-one hydrochloride;ALOSETRON HYDROCHLORIDE;2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one Hydrochloride;GR 68755;GR 68755X;Alosetron hydrocloride
3 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberA3197
  • Product descriptionAlosetron Hydrochloride
  • Packaging100MG
  • Price₹8400
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0346
  • Product descriptionAlosetron hydrochloride ≥98% (HPLC)
  • Packaging10MG
  • Price₹8075.45
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0346
  • Product descriptionAlosetron hydrochloride ≥98% (HPLC)
  • Packaging50MG
  • Price₹31046.1
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) A3197 Alosetron Hydrochloride 100MG ₹8400 2022-05-26 Buy
Sigma-Aldrich(India) SML0346 Alosetron hydrochloride ≥98% (HPLC) 10MG ₹8075.45 2022-06-14 Buy
Sigma-Aldrich(India) SML0346 Alosetron hydrochloride ≥98% (HPLC) 50MG ₹31046.1 2022-06-14 Buy

Properties

Melting point :288-291°C
storage temp. :2-8°C
solubility :H2O: ≥5mg/mL at warmed
form :powder
color :white to beige
CAS DataBase Reference :122852-69-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P273 Avoid release to the environment.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Lotronex (alosetron) was developed for the treatment of severe irritable bowel syndrome (IBS), and was approved for use by the US Food and Drug Administration (FDA) in 2000. Although Lotronex had a relatively high improvement rate in patients taking the drug for IBS, it was voluntarily pulled from the market by GlaxoWellcome that same year due to reports of severe adverse side effects, some resulting in death.
In 2002, Lotronex was reapproved in a supplemental New Drug Application for use under more restrictive conditions. Now with a risk management program to be consulted prior to administration of the drug, Lotronex is designated to be prescribed only when its medical benefits outweigh the risks of toxic effects; women with severe diarrhea-predominant IBS are now the focal point of prescriptions for Lotronex.

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