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Amiodarone-D4 HCl

Amiodarone-D4 HCl Structure
  • ₹0
  • Product name: Amiodarone-D4 HCl
  • CAS: 1216715-80-8
  • MF: C25H30ClI2NO3
  • MW: 681.78
  • EINECS:806-400-9
  • MDL Number:MFCD08064189
  • Synonyms:Amiodarone-D4 hydrochloride solution;(2-butyl-1-benzofuran-3-yl)-[3,5-diiodo-4-[1,1,2,2-tetradeuterio-2-(diethylamino)ethoxy]phenyl]methanone:hydrochloride;[2H4]-Amiodarone Hydrochloride;AMIODARONE HCL (D4, 98%) 100 UG/ML IN METHANOL (AS FREE BASE);Amiodarone hydrochloride salt;Amiodarone D4 HydrochlorideQ: What is Amiodarone D4 Hydrochloride Q: What is the CAS Number of Amiodarone D4 Hydrochloride Q: What is the storage condition of Amiodarone D4 Hydrochloride Q: What are the applications of Amiodarone D4 Hydrochloride;2H4]-Amiodarone hydrochloride salt;Prosulfocarb Impurity 3-d10
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Flash point :9℃
storage temp. :-20°C
solubility :DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml
form :A solid
color :White to off-white
Stability :Very Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P311 Call a POISON CENTER or doctor/physician.

Description

Amiodarone-d4 is intended for use as an internal standard for the quantification of amiodarone by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 μM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6 and 0.65 μM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.

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Dideiodo AMiodarone Hydrochloride 52490-15-0 869-24-9 2-Butylbenzofuran Di(N-desethyl) AMiodarone Hydrochloride 1951-26-4 Bis Des-iodo amiodarone HCl(Amiodarone impurity) 1189960-80-2 96027-74-6 [[p-(2-methoxyethyl)phenoxy]methyl]oxirane Amiodarone hydrochloride 3-(4-HYDROXY-3-IODOBENZOYL)-2-BUTYLBENZOFURAN 1-Methoxy AMiodarone

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Suppliers and manufacturers

Pharmaffiliates Analytics and Synthetics P. Ltd SynZeal Research Pvt Ltd Pharma Affiliates CLEARSYNTH LABS LTD. Changzhou Bojia Biomedical Technology Co., Ltd. Cerilliant Corporation Toronto Research Chemicals Riedel-de Haen AG Nanjing Haolv Biotechnology Co.,Ltd Shanghai Hao Zhun Biological Technology Co., Ltd.