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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Lipid regulating drugs >Atorvastatin calcium

Atorvastatin calcium

Atorvastatin calcium Structure
  • ₹0
  • Product name: Atorvastatin calcium
  • CAS: 134523-03-8
  • MF: C33H37CaFN2O5
  • MW: 600.74
  • EINECS:200-659-6
  • MDL Number:MFCD03613598
  • Synonyms:ATORVASTATIN CALCIUM;(3R,5R)-7-(2-(4-FLUOROPHENYL)-5-ISOPROPYL-3-PHENYL-4-(PHENYLCARBAMOYL)-1H-PYRROL-1-YL)-3,5-DIHYDROXYHEPTANOIC ACID CALCIUM;(3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-;(R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Calcium;3S,5S-Atorvastatin Calcium;Bis[(3R,5R)-3,5-dihydroxy-7-[2-(1-methylethyl)-3-[(phenylamino)carbonyl]-4-phenyl-5-(4-fluorophenyl)-1H-pyrrol-1-yl]heptanoic acid]calcium salt;Bis[(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-yl]-3,5-dihydroxyheptanoic acid] calcium salt;Bis[(3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-1-pyrrolyl]-3,5-dihydroxyheptanoic acid] calcium salt
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :176-178°C
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: ≥10mg/mL
form :white powder
color :White to Off-White
BCS Class :2
InChIKey :FQCKMBLVYCEXJB-MNSAWQCASA-L
CAS DataBase Reference :134523-03-8(CAS DataBase Reference)
EPA Substance Registry System :1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-.beta.,delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1),(.beta.R,.delta.R)- (134523-03-8)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P314 Get medical advice/attention if you feel unwell.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

The statins inhibit the enzyme HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway of cholesterol synthesis, thus lowering blood cholesterol levels. Statins also have additional cardiovascular benefits that appear to be independent of their effects on cholesterol synthesis. Atorvastatin is an HMG-CoA reductase inhibitor (IC50 = 154 nM) that is effective in treating hypercholesterolemia and certain dyslipidemias. It may also be used to prevent coronary or stroke events in hypertensive patients with normal cholesterol levels. In addition to inhibiting cholesterol synthesis, atorvastatin reduces the production of low-density lipoprotein (LDL). It is metabolized by cytochrome P450 3A4 (CYP3A4), producing several metabolites that are important in the therapeutic actions attributed to atorvastatin. As a result, inhibitors or inducers of CYP3A4 modify plasma concentrations of atorvastatin and its metabolites, altering the effectiveness of treatment.

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Suppliers and manufacturers

Jigs Chemical ltd Cadila Pharmaceuticals Ltd ANWITA APIS Apotex Pharmachem India Pvt Ltd Chemeca Drugs Private Limited (Vegesna Laboratories Pvt Ltd) Anuh Pharma Ltd (SK GROUP) Hetero Drugs Limited Mankind Pharma Limited Macleods Pharmaceuticals Limited Sun Pharmaceutical Industries Ltd