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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Metabolism >PDE inhibitors >Avanafil

Avanafil

Avanafil Structure
  • ₹3163.5 - ₹11888.1
  • Product name: Avanafil
  • CAS: 330784-47-9
  • MF: C23H26ClN7O3
  • MW: 483.95
  • EINECS:-0
  • MDL Number:MFCD11977961
  • Synonyms:4-[[(3-Chloro-4-Methoxyphenyl)Methyl] aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide;Avanafil 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide;avanfil;(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-yl;avanafil:4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)-1-pyrrolidinyl)-n-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide: (s)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylami;(S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2pyrimidinylmethyl)-5-pyrimidinecarboxamide;(S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine;4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
Price2 Properties Safety Information Description
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 100MG
  • 500MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2799
  • Product descriptionAvanafil ≥98% (HPLC)
  • Packaging100MG
  • Price₹3163.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2799
  • Product descriptionAvanafil ≥98% (HPLC)
  • Packaging500MG
  • Price₹11888.1
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML2799 Avanafil ≥98% (HPLC) 100MG ₹3163.5 2022-06-14 Buy
Sigma-Aldrich(India) SML2799 Avanafil ≥98% (HPLC) 500MG ₹11888.1 2022-06-14 Buy

Properties

Melting point :150-152°C
Density :1.372
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
form :Solid
pka :11.84±0.46(Predicted)
color :White to Off-White
InChIKey :WEAJZXNPAWBCOA-INIZCTEOSA-N
SMILES :C1(N2CCC[C@H]2CO)=NC=C(C(NCC2=NC=CC=N2)=O)C(NCC2=CC=C(OC)C(Cl)=C2)=N1
CAS DataBase Reference :330784-47-9(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Avanafil (Zepeed) was approved by the Korean Health Ministry for the treatment of erectile dysfunction (ED) in August 2011. Avanafil is a highly selective type 5 phosphodiesterase (PDE5) inhibitor. Avanafil is reported to be the most selective PDE5 inhibitor on the market. The onset of Tmax and half-life also varies among the marketed PDE5 inhibitors. Sildenafil has a Tmax at 1 h and a half-life of 3–5 h. Vardenafil is somewhat similar with a Tmax of 0.6 h and a half-life of 4–6 h. Tadalafil has the longest half-life among the marketed drugs with a half-life of 17 h. Avanafil has a fast onset of action reaching Tmax in 0.6 h with a half-life of 1.2 h. A synthesis of avanafil (TA-1790) is described in the patent literature. The main elimination route of avanafil is through the bile and feces. Avanafil was also found to be reabsorbed through enterohepatic recirculation.

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Suppliers and manufacturers

Honour Lab Limited BDR Pharmaceuticals International Pvt Ltd Rakshit Group of Companies (Rakshit Drugs Pvt Ltd) Century Pharmaceuticals Ltd HONOUR LAB LTD CLEARSYNTH LABS LTD. A.J Chemicals Pharmaffiliates Analytics and Synthetics P. Ltd SynZeal Research Pvt Ltd Pharma Affiliates