BEPOTASTINE BESILATE
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- Product name: BEPOTASTINE BESILATE
- CAS: 190786-44-8
- MF: C27H31ClN2O6S
- MW: 547.06
- EINECS:1806241-263-5
- MDL Number:MFCD01938491
- Synonyms:4-[4-[(4-chlorophenyl)-pyridin-2-ylMethoxy]piperidin-1-yl]butanoic acid benzenesulfonate;1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, benzenesulfonate (1:1);Benzenesulfonate salt ;BEPOTASTINE BESILATE;(+)-(S)-4-(4-((4-Chlorophenyl)(2-pyridyl)methoxy)piperidino)butyric acid monobenzenesulfonate;4-((4-Chlorophenyl)-2-pyridinylmethoxy)- (S)-1-piperidinebutanoic acid monobenzenesulfonate;Talion (TN);Bepotastine Beslilat
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Properties
Melting point :161-163°
alpha :D20 +6.0° (c = 5 in methanol)
storage temp. :Inert atmosphere,Room Temperature
solubility :DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form :Solid
color :White to Light Beige
Stability :Hygroscopic
alpha :D20 +6.0° (c = 5 in methanol)
storage temp. :Inert atmosphere,Room Temperature
solubility :DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form :Solid
color :White to Light Beige
Stability :Hygroscopic
Safety Information
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Description
Betotastine was introduced in Japan for the treatment of allergic rhinitis. This structurally-related derivative of chlorpheniramine and ebastine is prepared by condensation of optically-resolved 4-[1-(4-chlorophenyl)-1-(2-pyridyl)-methoxy]piperidine with ethyl 4-bromobutyrate followed by ester hydrolysis. Betotastine is the seventh marketed non-sedating histamine H1 antagonist. Its very low sedative side effect is due to very poor penetration in the central nervous system. Besides its potent and long-acting activity in models of allergic rhinitis, betotastine was also shown to act as a PAF antagonist and inhibit LTD4 in tracheal smooth muscle and ileum, IL-5 production by human peripheral blood mononuclear cells as well as eosinophil infiltration in the airway and peripheral blood. As a consequence, it is currently being developed against other allergic and respiratory disorders.More related product prices
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