BIBB 515
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- Product name: BIBB 515
- CAS: 156635-05-1
- MF: C22H21ClN2O2
- MW: 380.87
- EINECS:
- MDL Number:MFCD00930515
- Synonyms:BIBB 515;(4-chlorophenyl)-[4-[[4-(4,5-dihydro-1,3-oxazol-2-yl)phenyl]methylidene]piperidin-1-yl]methanone;Methanone, (4-chlorophenyl)[4-[[4-(4,5-dihydro-2-oxazolyl)phenyl]methylene]-1-piperidinyl]-;BIBB 515,Inhibitor,OSC,inhibit,cyclase,effect,metabolism,LDL,BIBB-515,2,3-oxidosqualene,BIBB515,sterol,cholesterol,lipid-lowering
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Properties
Boiling point :586.5±50.0 °C(Predicted)
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:1.38(Max Conc. mg/mL);3.62(Max Conc. mM)
DMF:0.3(Max Conc. mg/mL);0.79(Max Conc. mM)
Ethanol:0.15(Max Conc. mg/mL);0.39(Max Conc. mM) form :White solid.
pka :4.72±0.50(Predicted)
color :White to off-white
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:1.38(Max Conc. mg/mL);3.62(Max Conc. mM)
DMF:0.3(Max Conc. mg/mL);0.79(Max Conc. mM)
Ethanol:0.15(Max Conc. mg/mL);0.39(Max Conc. mM) form :White solid.
pka :4.72±0.50(Predicted)
color :White to off-white
Safety Information
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Description
BIBB 515 is a selective and potent inhibitor of 2,3-oxidosqualene cyclase (OSC) with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. Total cholesterol was reduced by 19% in normalipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic hamsters at a dose of 148 mg/kg/day for 25 days. OSC is an important enzyme in the biosynthesis of animal, fungal and plant sterols. OSC catalyzes the conversion of (3S)-2,3-oxidosqualene to lanosterol, a precursor to cholesterol, in fungi and mammals.More related product prices
RO 48-8071Related product price
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₹10670
Suppliers and manufacturers
TargetMol Chemicals Inc.
Aladdin Scientific
Cayman Chemical Company
Shanghai EFE Biological Technology Co., Ltd.
Resenbio
Beijing Baiao Innovation Technology Co., Ltd.
Shanghai Ziqi Biological Technology Co., Ltd.
Boao Pike
Beijing Bolide Biotechnology Co., Ltd.
Xiamen Huijia Biological Technology Co., Ltd.