Bilastine
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- ₹5800 - ₹10100
- Product name: Bilastine
- CAS: 202189-78-4
- MF: C28H37N3O3
- MW: 463.62
- EINECS:
- MDL Number:MFCD09837814
- Synonyms:4-[2-[4-[1-(2-Ethoxyethyl)-1H-benziMidazol-2-yl]-1-piperidinyl]ethyl]-α,α-diMethylbenzeneacetic Acid;Benzeneacetic acid,4-[2-[4-[1-(2-ethoxyethyl)-1H-benziMidazol-2-yl]-1-piperidinyl]ethyl]-a,a-diMethyl-;BENZENEACETIC ACID, 4-(2-(4-(1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOL-2-YL)-1-PIPERIDINYL)ETHYL-ALPHA, ALPHA-DIMETHYL-;2-[4-[2-[4-[1-(2-ethoxyethyl)benzoimidazol-2-yl]-1-piperidyl]ethyl]phenyl]-2-methyl-propanoic acid;4-[2-[4-[1-(2-Ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinyl]ethyl]-alpha,alpha-dimethylbenzeneacetic acid;Bilasten;2-[4-[2-[4-[1-(2-ethoxyethyl)benzimidazol-2-yl]piperidin-1-yl]ethyl]phenyl]-2-methylpropanoic acid;the impurity of Bilastine
2 prices
Selected condition：
Brand
- TCI Chemicals (India)
Package
- 250MG
- 1G
- ManufacturerTCI Chemicals (India)
- Product numberB5392
- Product descriptionBilastine
- Packaging1G
- Price₹10100
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberB5392
- Product descriptionBilastine
- Packaging250MG
- Price₹5800
- Updated2022-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | B5392 | Bilastine | 1G | ₹10100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B5392 | Bilastine | 250MG | ₹5800 | 2022-05-26 | Buy |
Properties
Melting point :202 °C
Boiling point :639.1±55.0 °C(Predicted)
Density :1.16±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
Water Solubility :Insoluble in water
solubility :DMSO:49.3(Max Conc. mg/mL);106.34(Max Conc. mM)
pka :4.40±0.10(Predicted)
form :powder to crystal
color :White to Light yellow
Boiling point :639.1±55.0 °C(Predicted)
Density :1.16±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
Water Solubility :Insoluble in water
solubility :DMSO:49.3(Max Conc. mg/mL);106.34(Max Conc. mM)
pka :4.40±0.10(Predicted)
form :powder to crystal
color :White to Light yellow
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Bilastine, a potent and selective histamine H1 receptor antagonist, was approved in Europe in 2010 for the treatment of allergic rhinoconjunctivitis (AR) and urticaria (hives or skin rash). The original synthesis of bilastine involves alkylation of 2-piperidinyl-1H-benzimidazole with a phenethyltosylate, the para position of which is substituted with a dimethyloxazoline moiety serving as a masked carboxylic acid group. Alkylation of the benzimidazole nitrogen with 2-chloroethyl ethyl ether followed by unmasking of the oxazoline moiety with sulfuric acid provided bilastine.In two major clinical trials, bilastine was effective at relieving allergic rhinitis as assessed by measuring the severity of nasal (obstruction, rhinorrhea, itching, sneezing) and nonnasal (ocular itching, tearing, ocular redness, itching of ears, and/or palate) symptoms.
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