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ChemicalBook > Product Catalogue >API >Urinary System Drugs >Diuretics Drugs >Bumetanide

Bumetanide

Bumetanide Structure
  • ₹9320.33 - ₹25839.28
  • Product name: Bumetanide
  • CAS: 28395-03-1
  • MF: C17H20N2O5S
  • MW: 364.42
  • EINECS:249-004-6
  • MDL Number:MFCD00078949
  • Synonyms:segurex ;pf1593 ;lunetoron ;fordiuran ;fontego ;burine ;Bumetanide (Ro 10-6338);Bemetanide
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 250MG
  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product numberB3023
  • Product descriptionBumetanide ≥98%
  • Packaging250MG
  • Price₹9320.33
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB3023
  • Product descriptionBumetanide ≥98%
  • Packaging1G
  • Price₹25839.28
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) B3023 Bumetanide ≥98% 250MG ₹9320.33 2022-06-14 Buy
Sigma-Aldrich(India) B3023 Bumetanide ≥98% 1G ₹25839.28 2022-06-14 Buy

Properties

Melting point :230-2310C
Boiling point :571.2±60.0 °C(Predicted)
Density :1.2812 (rough estimate)
refractive index :1.6510 (estimate)
storage temp. :2-8°C
solubility :Practically insoluble in water, soluble in acetone and in alcohol, slightly soluble in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.
form :Solid
pka :pK1 3.6, pK2 7.7(at 25℃)
color :White to Light Yellow
Water Solubility :Soluble in ethanol (10 mg/ml), DMSO (25 mg/ml), acetone, benzene, methanol, propylene glycol, and water (<1 mg/ml).
CAS DataBase Reference :28395-03-1(CAS DataBase Reference)
EPA Substance Registry System :Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy- (28395-03-1)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Bumetanide is a loop diuretic with good absorption and pharmacodynamic properties. It acts as an inhibitor of the Na-K-Cl cotransporter 1 (NKCC1) and the kidney-specific NKCC2 (Ki = 0.5 and 59 μM for human and rabbit NKCC1, respectively). Bumetanide also inhibits several isoforms of carbonic anhydrase.

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