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ChemicalBook > Product Catalogue >API >Antiparasitic drugs >Antimalarial drugs >CHLOROQUINE

CHLOROQUINE

CHLOROQUINE Structure
  • ₹0
  • Product name: CHLOROQUINE
  • CAS: 54-05-7
  • MF: C18H26ClN3
  • MW: 319.87
  • EINECS:200-191-2
  • MDL Number:MFCD00024009
  • Synonyms:sn7618 ;Solprina;Sopaquin;Tanakan;Tresochin;Trochin;W 7618;w7618
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :87°
Boiling point :475.41°C (rough estimate)
Density :1.0500 (rough estimate)
refractive index :1.6010 (estimate)
storage temp. :2-8°C(protect from light)
solubility :Chloroform (Slightly), Methanol (Slightly)
form :Solid
pka :pKa 8.4(H2O t = 20) (Uncertain)
color :White to Light Brown
Stability :Stable, but light sensitive. Incompatible with strong oxidizing agents.
IARC :3 (Vol. 13, Sup 7) 1987
EPA Substance Registry System :1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl- (54-05-7)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

Chloroquine is the most effective of the hundreds of 4-aminoquinolines synthesized and tested during World War II as potential antimalarials. Structure–activity relationships demonstrated that the chloro at the 8-position increased activity, whereas alkylation at C-3 and C-8 diminished activity. The replacement of one of its N-ethyl groups with an hydroxyethyl produced hydroxychloroquine, a compound with reduced toxicity that is rarely used today except in cases of rheumatoid arthritis.

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