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ChemicalBook > Product Catalogue >API >Antibiotics >Other antibiotic Drugs >CONCANAMYCIN A

CONCANAMYCIN A

CONCANAMYCIN A Structure
  • ₹20978.85 - ₹63163.88
  • Product name: CONCANAMYCIN A
  • CAS: 80890-47-7
  • MF: C46H75NO14
  • MW: 866.09
  • EINECS:620-709-4
  • MDL Number:MFCD00210037
  • Synonyms:CONCANAMYCIN A;CONCANAMYCIN A, STREPTOMYCES SP;concanamycin A from streptomyces species;A661-I;Antibiotic A661I;Antibiotic S-45A;S-45A;(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 0.1MG
  • 250μG
  • 25μG
  • 50μG
  • ManufacturerSigma-Aldrich(India)
  • Product numberC9705
  • Product descriptionConcanamycin A ≥70% (HPLC)
  • Packaging25μG
  • Price₹20978.85
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number27689
  • Product descriptionConcanamycin A from Streptomyces sp., ≥80% (HPLC)
  • Packaging50μG
  • Price₹28794.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC9705
  • Product descriptionConcanamycin A ≥70% (HPLC)
  • Packaging0.1MG
  • Price₹58671.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number27689
  • Product descriptionConcanamycin A from Streptomyces sp., ≥80% (HPLC)
  • Packaging250μG
  • Price₹63163.88
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) C9705 Concanamycin A ≥70% (HPLC) 25μG ₹20978.85 2022-06-14 Buy
Sigma-Aldrich(India) 27689 Concanamycin A from Streptomyces sp., ≥80% (HPLC) 50μG ₹28794.5 2022-06-14 Buy
Sigma-Aldrich(India) C9705 Concanamycin A ≥70% (HPLC) 0.1MG ₹58671.5 2022-06-14 Buy
Sigma-Aldrich(India) 27689 Concanamycin A from Streptomyces sp., ≥80% (HPLC) 250μG ₹63163.88 2022-06-14 Buy

Properties

Melting point :179-180℃ (dichloromethane ethanol )
Boiling point :966.4±65.0 °C(Predicted)
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :Soluble in DMSO
form :Lyophilized solid
pka :12.46±0.70(Predicted)
color :White
BRN :3560277
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The vacuolar H+-ATPase (V-ATPase) is a multisubunit complex that establishes pH gradients along secretory and endocytic pathways by catalyzing ATP hydrolysis via the V1 domain and driving proton translocation through the V0 domain. Concanamycin A is a plecomacrolide antibiotic produced by Streptomyces that blocks lysosomal acidification through selective inhibition of the V-type ATPase (EC50 = 2.1-2.3 μM). Concanamycin A blocks cell surface expression of viral glycoproteins without affecting their synthesis and, at 0.8 μM, prevents entry of influenza virus into cells.

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