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ChemicalBook > Product Catalogue >Biochemical Engineering >Chinese Herbs >CUCURBITACIN B

CUCURBITACIN B

CUCURBITACIN B Structure
  • ₹7100 - ₹103292.15
  • Product name: CUCURBITACIN B
  • CAS: 6199-67-3
  • MF: C32H46O8
  • MW: 558.7
  • EINECS:
  • MDL Number:MFCD07778083
  • Synonyms:(2beta,9beta,10alpha,16alpha,23e)-thyl ;19-nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione,2-beta,16-alpha,20,25 ;19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,2beta,16alpha,20,25-tet ;19-norlanosta-5,23-diene-3,11,22-trione,25-(acetyloxy)-2,16,20-trihydroxy-9-me ;25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-tr ;Cucurbitacin B hydrate;cucurbitacineb ;AMARINE
4 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerTCI Chemicals (India)
  • Product numberC3442
  • Product descriptionCucurbitacin B
  • Packaging5MG
  • Price₹7100
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC3442
  • Product descriptionCucurbitacin B
  • Packaging25MG
  • Price₹17800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC8499
  • Product descriptionCucurbitacin B hydrate ≥97% (HPLC)
  • Packaging5MG
  • Price₹26542.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC8499
  • Product descriptionCucurbitacin B hydrate ≥97% (HPLC)
  • Packaging25MG
  • Price₹103292.15
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C3442 Cucurbitacin B 5MG ₹7100 2022-05-26 Buy
TCI Chemicals (India) C3442 Cucurbitacin B 25MG ₹17800 2022-05-26 Buy
Sigma-Aldrich(India) C8499 Cucurbitacin B hydrate ≥97% (HPLC) 5MG ₹26542.9 2022-06-14 Buy
Sigma-Aldrich(India) C8499 Cucurbitacin B hydrate ≥97% (HPLC) 25MG ₹103292.15 2022-06-14 Buy

Properties

Melting point :184-186°
alpha :D25 +88° (c = 1.55 in ethanol)
Boiling point :546.74°C (rough estimate)
Density :1.0953 (rough estimate)
refractive index :1.4900 (estimate)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :12.60±0.29(Predicted)
color :white to beige
λmax :290nm(EtOH)(lit.)
Merck :14,2614
Stability :Hygroscopic
InChIKey :IXQKXEUSCPEQRD-ALLWXVAWSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Cucurbitacin B is a plant-derived triterpene that has the classic four-ring structure of mammalian steroids. It has diverse effects on mammalian cells, most notably inducing cell cycle arrest or apoptosis in a range of cancer cell lines. Cucurbitacin B inhibits the growth of several breast cancer cell lines (IC50s = 18-50 nM). It suppresses the growth of tumors developed from MDA-MB-231 and 4T-1 breast cancer cells in mice. Cucurbitacin B blocks the inflammatory response of macrophages treated with lipopolysaccharide. In Drosophila, it serves as an ecdysteroid receptor antagonist (Kd = 5 μM).

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