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ChemicalBook > Product Catalogue >Biochemical Engineering >Chinese Herbs >Cucurbitacin E

Cucurbitacin E

Cucurbitacin E Structure
  • ₹24745.95 - ₹99395.15
  • Product name: Cucurbitacin E
  • CAS: 18444-66-1
  • MF: C32H44O8
  • MW: 556.69
  • EINECS:242-325-2
  • MDL Number:MFCD00135936
  • Synonyms:A-ELATERIN;ALPHA-ELATERIN;CUCURBITACIN E;CUCURBITACIN E(SH);19-nor-9-beta,10-alpha-lanosta-1,5,23-triene-3,11,22-trione,2,16-alpha,20,25-t ;25-acetate ;alpha-elaterine ;cucurbitacine-e
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0577
  • Product descriptionCucurbitacin E ≥95% (HPLC)
  • Packaging5MG
  • Price₹24745.95
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0577
  • Product descriptionCucurbitacin E ≥95% (HPLC)
  • Packaging25MG
  • Price₹99395.15
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0577 Cucurbitacin E ≥95% (HPLC) 5MG ₹24745.95 2022-06-14 Buy
Sigma-Aldrich(India) SML0577 Cucurbitacin E ≥95% (HPLC) 25MG ₹99395.15 2022-06-14 Buy

Properties

Melting point :228-234°C
alpha :D -59° (c = 0.7 in chloroform)
Boiling point :545.56°C (rough estimate)
Density :1.1059 (rough estimate)
refractive index :1.4900 (estimate)
storage temp. :-20°C
solubility :DMSO: soluble15mg/mL, clear
form :powder
pka :8.51±0.70(Predicted)
color :white to beige
optical activity :[α]/D -60 to -75°, c = 0.7 (CDCl3)
InChIKey :NDYMQXYDSVBNLL-MUYMLXPFSA-N
LogP :3.150 (est)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:

Description

Cucurbitacin E is a plant-derived triterpene that has diverse biological activities. At a concentration of 10 pM, it reduces MPP+-induced death of neuronal PC12 cells through inhibition of autophagy in vitro. Cucurbitacin E inhibits growth of T24 bladder, MDA-MB-468 and MCF-7 breast, PC3 prostate, and colorectal cancer cell lines (IC50s = 50-1,000 nM) through induction of G2/M arrest and apoptosis. It increases bilirubin binding to human serum albumin (HSA) in human plasma in a dose-dependent manner. Cucurbitacin E also inhibits depolymerization of actin filaments isolated from rabbit skeletal muscle actin and in HeLa cells.

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Cucurbitacin E CAS:18444-66-1
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