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ChemicalBook > Product Catalogue >API >Nervous system drugs >Antiepileptic and anticonvulsant >Carbamazepine

Carbamazepine

Carbamazepine Structure
  • ₹3063.48 - ₹25666.08
  • Product name: Carbamazepine
  • CAS: 298-46-4
  • MF: C15H12N2O
  • MW: 236.27
  • EINECS:206-062-7
  • MDL Number:MFCD00005073
  • Synonyms:CarbaMazepine (D10, 98%);CarbaMazepine-13C6;Carbamazepine solution ;CARBAMAZEPINE;ANBROMINE;5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE;5-Carbamoyl-5H-dibenzo(b,f)azepine;5-Carbamoyldibenzo(b,f)azepine
Price11 Properties Safety Information Description
11 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 100MG
  • 1ML
  • 1G
  • 5G
  • 10G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberC1095
  • Product descriptionCarbamazepin
  • Packaging10G
  • Price₹5200
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC1095
  • Product descriptionCarbamazepin
  • Packaging25G
  • Price₹9400
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC4024
  • Product descriptionCarbamazepine powder
  • Packaging1G
  • Price₹3063.48
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC-053
  • Product descriptionCarbamazepine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹3311.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number94496
  • Product descriptionCarbamazepine analytical standard
  • Packaging100MG
  • Price₹5802.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC8981
  • Product descriptionCarbamazepine meets USP testing specifications
  • Packaging5G
  • Price₹7609.98
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC4024
  • Product descriptionCarbamazepine powder
  • Packaging5G
  • Price₹8151.23
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1067
  • Product descriptionCarbamazepine Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹8465.15
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC4024
  • Product descriptionCarbamazepine powder
  • Packaging10G
  • Price₹13163.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC8981
  • Product descriptionCarbamazepine meets USP testing specifications
  • Packaging25G
  • Price₹21227.83
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC4024
  • Product descriptionCarbamazepine powder
  • Packaging25G
  • Price₹25666.08
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C1095 Carbamazepin 10G ₹5200 2022-05-26 Buy
TCI Chemicals (India) C1095 Carbamazepin 25G ₹9400 2022-05-26 Buy
Sigma-Aldrich(India) C4024 Carbamazepine powder 1G ₹3063.48 2022-06-14 Buy
Sigma-Aldrich(India) C-053 Carbamazepine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹3311.7 2022-06-14 Buy
Sigma-Aldrich(India) 94496 Carbamazepine analytical standard 100MG ₹5802.2 2022-06-14 Buy
Sigma-Aldrich(India) C8981 Carbamazepine meets USP testing specifications 5G ₹7609.98 2022-06-14 Buy
Sigma-Aldrich(India) C4024 Carbamazepine powder 5G ₹8151.23 2022-06-14 Buy
Sigma-Aldrich(India) PHR1067 Carbamazepine Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹8465.15 2022-06-14 Buy
Sigma-Aldrich(India) C4024 Carbamazepine powder 10G ₹13163.2 2022-06-14 Buy
Sigma-Aldrich(India) C8981 Carbamazepine meets USP testing specifications 25G ₹21227.83 2022-06-14 Buy
Sigma-Aldrich(India) C4024 Carbamazepine powder 25G ₹25666.08 2022-06-14 Buy

Properties

Melting point :191-192 °C (lit.)
Boiling point :378.73°C (rough estimate)
Density :1.1099 (rough estimate)
refractive index :1.5906 (estimate)
Flash point :9℃
storage temp. :2-8°C
solubility :45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble29mg/mL
pka :13.94±0.20(Predicted)
form :Crystals
color :Almost white
Water Solubility :pract. insoluble
Merck :14,1781
BCS Class :2
LogP :2.450
CAS DataBase Reference :298-46-4(CAS DataBase Reference)
NIST Chemistry Reference :Carbamazepine(298-46-4)
EPA Substance Registry System :5H-Dibenz[b,f]azepine-5-carboxamide (298-46-4)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
Precautionary statements:
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Carbamazepine (CBZ) is a first generation anticonvulsant and mood stabilizing compound that has been used as a therapeutic in the context of neuropathic pain, epilepsy, and affective disorders. It exerts its effects by blocking voltage-gated sodium channels (IC50 = 640 μM), making fewer of these channels available to subsequently open, which leads to decreased high-frequency repetitive firing of action potentials. The estimated IC50 values for inhibition of Nav1.7-, Nav1.3-, and Nav1.8-type channels by CBZ following prolonged inactivation have been reported as 406, 900, and 138 μM, respectively. CBZ can also inhibit L-type Ca2+ channels (IC50 = 974 μM) and has been shown to potentiate GABAA receptors (IC50 >3 mM).

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