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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Antihypertensive drugs >Clonidine hydrochloride

Clonidine hydrochloride

Clonidine hydrochloride Structure
  • ₹6982.13 - ₹139685.8
  • Product name: Clonidine hydrochloride
  • CAS: 4205-91-8
  • MF: C9H10Cl3N3
  • MW: 266.55
  • EINECS:224-121-5
  • MDL Number:MFCD00036705
  • Synonyms:CLONIDINE HYDROCHLORIDE;DIXARIT;2-[2,6-DICHLOROANILINE]-2-IMIDAZOLINE HYDROCHLORIDE;2-(2,6-DICHLOROANILINO)-2-IMIDAZOLINE, HCL;2-(2,6-DICHLOROPHENYLAMINO)-2-IMIDAZOLINE HYDROCHLORIDE;katapresan ;klophelin ;n-(2,6-dichlorophenyl)-4,5-dihydro-1h-imidazol-2-aminmonohydrochloride
6 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 100MG
  • 250MG
  • 1G
  • 5G
  • ManufacturerTCI Chemicals (India)
  • Product numberD1353
  • Product descriptionClonidine Hydrochloride
  • Packaging1G
  • Price₹7400
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberD1353
  • Product descriptionClonidine Hydrochloride
  • Packaging5G
  • Price₹19600
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7897
  • Product descriptionClonidine hydrochloride solid
  • Packaging100MG
  • Price₹6982.13
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7897
  • Product descriptionClonidine hydrochloride solid
  • Packaging250MG
  • Price₹15501.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7897
  • Product descriptionClonidine hydrochloride solid
  • Packaging1G
  • Price₹50401.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7897
  • Product descriptionClonidine hydrochloride solid
  • Packaging5G
  • Price₹139685.8
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) D1353 Clonidine Hydrochloride 1G ₹7400 2022-05-26 Buy
TCI Chemicals (India) D1353 Clonidine Hydrochloride 5G ₹19600 2022-05-26 Buy
Sigma-Aldrich(India) C7897 Clonidine hydrochloride solid 100MG ₹6982.13 2022-06-14 Buy
Sigma-Aldrich(India) C7897 Clonidine hydrochloride solid 250MG ₹15501.4 2022-06-14 Buy
Sigma-Aldrich(India) C7897 Clonidine hydrochloride solid 1G ₹50401.2 2022-06-14 Buy
Sigma-Aldrich(India) C7897 Clonidine hydrochloride solid 5G ₹139685.8 2022-06-14 Buy

Properties

Melting point :312 °C
storage temp. :2-8°C
solubility :H2O: 50 mg/mL, clear, colorless
form :solid
color :white
PH :pH(50g/l, 25℃) : 3.5~6.0
Water Solubility :Soluble in water (50 mg/ml), DMSO (75 mM), methanol, chloroform (slightly), and dehydrated alcohol.
Merck :14,2390
BRN :4163525
BCS Class :1 (LogP), 3 (CLogP)
Stability :Hygroscopic
InChIKey :GLEWMLFXCSBZLK-UHFFFAOYSA-N
CAS DataBase Reference :4205-91-8(CAS DataBase Reference)
EPA Substance Registry System :1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-, hydrochloride (1:1) (4205-91-8)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger GHS hazard pictograms P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Description

Clonidine is a centrally acting α2-adrenergic receptor agonist that decreases peripheral vascular resistance by centrally inhibiting sympathetic nerve activity. In isolated mesenteric arteries precontracted with norepinephrine, clonidine induces relaxation at 10 μM. It can also open K+ channels and hyperpolarize mensenteric artery plasma membrane at this concentration. The antihypertensive effects of clonidine have also been attributed to its agonism of the imidazoline (I1) receptor (Ki = 4-8 nM), which mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure.

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