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ChemicalBook > Product Catalogue >API >Synthetic Anti-infective Drugs >Antifungal Drugs >Clotrimazole

Clotrimazole

Clotrimazole Structure
  • ₹3700 - ₹88277.88
  • Product name: Clotrimazole
  • CAS: 23593-75-1
  • MF: C22H17ClN2
  • MW: 344.84
  • EINECS:245-764-8
  • MDL Number:MFCD00057220
  • Synonyms:component of Otomax;Empecid;FB 5097;fb5097 ;Gyne lotrimin;Imidazole, 1-(o-chloro-alpha,alpha-diphenylbenzyl)-;Methane, bis-phenyl-(2-chlorophenyl)-1-imidazolyl-;Mono-baycuten
7 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 100MG
  • 1G
  • 5G
  • 25G
  • 100G
  • ManufacturerTCI Chemicals (India)
  • Product numberC2867
  • Product descriptionClotrimazole
  • Packaging5G
  • Price₹3700
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC2867
  • Product descriptionClotrimazole
  • Packaging25G
  • Price₹13400
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1058
  • Product descriptionClotrimazole Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹8356.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number33894
  • Product descriptionClotrimazole VETRANAL?, analytical standard
  • Packaging100MG
  • Price₹9309.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC6019
  • Product descriptionClotrimazole
  • Packaging5G
  • Price₹10143.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC6019
  • Product descriptionClotrimazole
  • Packaging25G
  • Price₹32388.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC6019
  • Product descriptionClotrimazole
  • Packaging100G
  • Price₹88277.88
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C2867 Clotrimazole 5G ₹3700 2022-05-26 Buy
TCI Chemicals (India) C2867 Clotrimazole 25G ₹13400 2022-05-26 Buy
Sigma-Aldrich(India) PHR1058 Clotrimazole Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹8356.9 2022-06-14 Buy
Sigma-Aldrich(India) 33894 Clotrimazole VETRANAL?, analytical standard 100MG ₹9309.5 2022-06-14 Buy
Sigma-Aldrich(India) C6019 Clotrimazole 5G ₹10143.03 2022-06-14 Buy
Sigma-Aldrich(India) C6019 Clotrimazole 25G ₹32388.4 2022-06-14 Buy
Sigma-Aldrich(India) C6019 Clotrimazole 100G ₹88277.88 2022-06-14 Buy

Properties

Melting point :147-149°C
Boiling point :501.14°C (rough estimate)
Density :1.1095 (rough estimate)
refractive index :1.5940 (estimate)
storage temp. :2-8°C
solubility :Soluble in chloroform, DMSO, DMF and alcohols
pka :pKa 4.7(EtOH 50%aq ) (Uncertain)
form :Solid
color :White to Almost white
Water Solubility :<10mg/L(25 ºC)
λmax :556nm(Phosphate buffer sol.)(lit.)
Merck :14,2417
InChI :InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey :VNFPBHJOKIVQEB-UHFFFAOYSA-N
SMILES :C1N(C(C2=CC=CC=C2Cl)(C2=CC=CC=C2)C2=CC=CC=C2)C=CN=1
NIST Chemistry Reference :Clotrimazole(23593-75-1)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Clotrimazole is an imidazole antifungal that is active against a wide variety of fungal forms and is effective in many types of fungal infections. It tightly binds sterol 14-α demethylase isoform B from A. fumigatus (KD = 103 nM) and, like other imidazoles, disturbs the fungal cell membrane. In mammalian cells, clotrimazole potently inhibits the calcium-dependent potassium channels Kv1.3 and IK-1 (IC50 = 6.0 and 0.07 μM, respectively).

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