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ChemicalBook > Product Catalogue >Biochemical Engineering >Enzymes And Coenzymes drugs >Collagenase

Collagenase

Collagenase Structure
  • ₹4018.2 - ₹580574.4
  • Product name: Collagenase
  • CAS: 9001-12-1
  • MF: C60H100N2
  • MW: 849.4494
  • EINECS:232-582-9
  • MDL Number:MFCD00130830
  • Synonyms:COLLAGENASE TYPE X;Collagenase from Clostridium histolyticum;collagenase crude type ia cell culture*tested;collagenase F. clostridium histolyticum;collagenase from achromobacter iophagus;collagenase sterile filtered type vii-S;collagenase type I-S;Matrix metalloprotease-1
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  • Sigma-Aldrich(India)

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  • ManufacturerSigma-Aldrich(India)
  • Product numberV900893
  • Product descriptionCollagenase from Clostridium histolyticum Type IV, Vetec?, reagent grade, powder, ≥160?CDU/mg solid
  • Packaging1G
  • Price₹20712.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC8176
  • Product descriptionCollagenase from Clostridium histolyticum Sigma Blend Type L, ≤1.0?FALGPA units/mg solid
  • Packaging100MG
  • Price₹22854.9
  • Updated2022-06-14
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  • ManufacturerSigma-Aldrich(India)
  • Product numberC8051
  • Product descriptionCollagenase from Clostridium histolyticum Sigma Blend Type H, ≥1.0?FALGPA units/mg solid
  • Packaging100MG
  • Price₹24719.7
  • Updated2022-06-14
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  • ManufacturerSigma-Aldrich(India)
  • Product numberC2399
  • Product descriptionCollagenase from Clostridium histolyticum 0.2 μm filtered, high purity, purified by chromatography, Type VII-S, ≥4?FALGPA units/mg solid, ≥700?CDU/mg solid (CDU = collagen digestion units)
  • Packaging1500UNITS
  • Price₹27361.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC0255
  • Product descriptionCollagenase from Clostridium histolyticum purified by chromatography, ≥0.25?FALGPA units/mg solid, ≥250?CDU/mg solid (CDU = collagen digestion units), lyophilized powder
  • Packaging1500UNITS
  • Price₹27783.3
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7657
  • Product descriptionCollagenase from Clostridium histolyticum release of physiologically active rat pancreatic islets tested, Type XI, 2-5?FALGPA units/mg solid, ≥800?CDU/mg solid
  • Packaging100MG
  • Price₹13375.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC9697
  • Product descriptionCollagenase from Clostridium histolyticum lyophilized powder (from 0.2 μm filtered solution), Suitable for digestion and isolation of physiologically active pancreatic islet cells, suitable fo
  • Packaging50MG
  • Price₹14851.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC0773
  • Product descriptionCollagenase from Clostridium histolyticum high purity, purified by chromatography, Type VII, ≥4?FALGPA units/mg solid, lyophilized powder, ≥700?CDU/mg solid (CDU = collagen digestion units)
  • Packaging3000UNITS
  • Price₹15451.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7926
  • Product descriptionCollagenase from Clostridium histolyticum Sigma Blend Type F, ≥2.0?FALGPA units/mg solid
  • Packaging100MG
  • Price₹15961.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC9407
  • Product descriptionCollagenase from Clostridium histolyticum powder, Suitable for the digestion and isolation of physiologically active pancreatic islet cells, suitable for cell culture
  • Packaging100MG
  • Price₹15995.1
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberV900891
  • Product descriptionCollagenase from Clostridium histolyticum Type I, for general use, Vetec?, reagent grade, powder, ≥125?CDU/mg solid
  • Packaging1G
  • Price₹20712.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC1889
  • Product descriptionCollagenase from Clostridium histolyticum 0.2 μm filtered, release of physiologically active rat hepatocytes tested, Type II, 0.5-5.0?FALGPA units/mg solid, ≥125?CDU/mg solid
  • Packaging50MG
  • Price₹10101
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC9722
  • Product descriptionCollagenase from Clostridium histolyticum lyophilized powder (from 0.2μm filtered solution), 0.5-5.0?FALGPA units/mg solid, suitable for cell culture
  • Packaging50MG
  • Price₹10167.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC5894
  • Product descriptionCollagenase from Clostridium histolyticum non-sterile; 0.2 μm filtered, Type IA-S, 0.5-5.0?FALGPA units/mg solid, ≥125?CDU/mg solid
  • Packaging50MG
  • Price₹10200.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC1639
  • Product descriptionCollagenase from Clostridium histolyticum 0.2 μm filtered, for general use, Type I-S, 0.2-1.0?FALGPA units/mg solid, ≥125?CDU/mg solid
  • Packaging50MG
  • Price₹10200.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC2674
  • Product descriptionCollagenase from Clostridium histolyticum lyophilized powder, ≥125?CDU/mg solid (CDU = collagen digestion units), 0.5-5.0?FALGPA units/mg solid
  • Packaging100MG
  • Price₹10678.2
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) V900893 Collagenase from Clostridium histolyticum Type IV, Vetec?, reagent grade, powder, ≥160?CDU/mg solid 1G ₹20712.6 2022-06-14 Buy
Sigma-Aldrich(India) C8176 Collagenase from Clostridium histolyticum Sigma Blend Type L, ≤1.0?FALGPA units/mg solid 100MG ₹22854.9 2022-06-14 Buy
Sigma-Aldrich(India) C8051 Collagenase from Clostridium histolyticum Sigma Blend Type H, ≥1.0?FALGPA units/mg solid 100MG ₹24719.7 2022-06-14 Buy
Sigma-Aldrich(India) C2399 Collagenase from Clostridium histolyticum 0.2 μm filtered, high purity, purified by chromatography, Type VII-S, ≥4?FALGPA units/mg solid, ≥700?CDU/mg solid (CDU = collagen digestion units) 1500UNITS ₹27361.5 2022-06-14 Buy
Sigma-Aldrich(India) C0255 Collagenase from Clostridium histolyticum purified by chromatography, ≥0.25?FALGPA units/mg solid, ≥250?CDU/mg solid (CDU = collagen digestion units), lyophilized powder 1500UNITS ₹27783.3 2022-06-14 Buy
Sigma-Aldrich(India) C7657 Collagenase from Clostridium histolyticum release of physiologically active rat pancreatic islets tested, Type XI, 2-5?FALGPA units/mg solid, ≥800?CDU/mg solid 100MG ₹13375.5 2022-06-14 Buy
Sigma-Aldrich(India) C9697 Collagenase from Clostridium histolyticum lyophilized powder (from 0.2 μm filtered solution), Suitable for digestion and isolation of physiologically active pancreatic islet cells, suitable fo 50MG ₹14851.8 2022-06-14 Buy
Sigma-Aldrich(India) C0773 Collagenase from Clostridium histolyticum high purity, purified by chromatography, Type VII, ≥4?FALGPA units/mg solid, lyophilized powder, ≥700?CDU/mg solid (CDU = collagen digestion units) 3000UNITS ₹15451.2 2022-06-14 Buy
Sigma-Aldrich(India) C7926 Collagenase from Clostridium histolyticum Sigma Blend Type F, ≥2.0?FALGPA units/mg solid 100MG ₹15961.8 2022-06-14 Buy
Sigma-Aldrich(India) C9407 Collagenase from Clostridium histolyticum powder, Suitable for the digestion and isolation of physiologically active pancreatic islet cells, suitable for cell culture 100MG ₹15995.1 2022-06-14 Buy
Sigma-Aldrich(India) V900891 Collagenase from Clostridium histolyticum Type I, for general use, Vetec?, reagent grade, powder, ≥125?CDU/mg solid 1G ₹20712.6 2022-06-14 Buy
Sigma-Aldrich(India) C1889 Collagenase from Clostridium histolyticum 0.2 μm filtered, release of physiologically active rat hepatocytes tested, Type II, 0.5-5.0?FALGPA units/mg solid, ≥125?CDU/mg solid 50MG ₹10101 2022-06-14 Buy
Sigma-Aldrich(India) C9722 Collagenase from Clostridium histolyticum lyophilized powder (from 0.2μm filtered solution), 0.5-5.0?FALGPA units/mg solid, suitable for cell culture 50MG ₹10167.6 2022-06-14 Buy
Sigma-Aldrich(India) C5894 Collagenase from Clostridium histolyticum non-sterile; 0.2 μm filtered, Type IA-S, 0.5-5.0?FALGPA units/mg solid, ≥125?CDU/mg solid 50MG ₹10200.9 2022-06-14 Buy
Sigma-Aldrich(India) C1639 Collagenase from Clostridium histolyticum 0.2 μm filtered, for general use, Type I-S, 0.2-1.0?FALGPA units/mg solid, ≥125?CDU/mg solid 50MG ₹10200.9 2022-06-14 Buy
Sigma-Aldrich(India) C2674 Collagenase from Clostridium histolyticum lyophilized powder, ≥125?CDU/mg solid (CDU = collagen digestion units), 0.5-5.0?FALGPA units/mg solid 100MG ₹10678.2 2022-06-14 Buy

Properties

storage temp. :-20°C
solubility :Soluble in aqueous buffers.
form :powder
color :light brown
PH :7.0
Merck :2481
InChIKey :YRQNKMKHABXEJZ-UVQQGXFZSA-N
CAS DataBase Reference :9001-12-1
EPA Substance Registry System :Collagenase (9001-12-1)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Description

Collagenases are a category of enzymes that can digest native collagen, the major fibrous component of animal extracellular connective tissue. Collagenases can be produced by some bacterias such as Clostridium  and can also be made by the animal body as part of its normal immune response. They normally target the connective tissue in muscle cells and other body organs. They can break peptide bonds within collagen and help create collagen by cleaving pro-collagen, collagen's precursor, once it is secreted by the cell. Bacterial collagenases exhibit broader substrate specificity than animal collagenases and unlike animal collagenases that split collagen in its native triple-helical conformation, bacterial collagenase can degrade both water-insoluble native collagens and water-soluble denatured ones. In addition, bacterial collagenase can attack almost all collagen types, and is able to make multiple cleavages within triple helical regions.  Collagenases have a molecular weight ranging from 68 kilodaltons (kDa) to 130 Kda due to differing sizes based on the class to which the isolate belongs. The optimal pH for stability ranges from approximately 6.3 to 7.5 with a theoretical isoelectric point of 5.62. Numerous compounds and molecules have the capability of acting as collagenases activator or inhibitor. For example, Ca2+ and Zn2+ ions are two known activators. On the other hand, ethylenediaminetetraacetic acid (EDTA), ethylene glycol tetraacetic acid (EGTA), cysteine, histidine, dithiothreitol (DTT), 2-mercaptoethanol, o-phenanthroline, Hg2+, Pb2+, Cd2+, Cu2+, and Zn2+ are all known inhibitors of collagenase activity.

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