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ChemicalBook > Product Catalogue >API >Hormones and the Endocrine System >Adrenal corticosteroids >Cortisone acetate

Cortisone acetate

Cortisone acetate Structure
  • ₹6386.75 - ₹74270.33
  • Product name: Cortisone acetate
  • CAS: 50-04-4
  • MF: C23H30O6
  • MW: 402.48
  • EINECS:200-006-5
  • MDL Number:MFCD00003609
  • Synonyms:11,20-trione,17,21-dihydroxy-pregn-4-ene-21-acetate ;11-dehydro-17-hydroxycorticosterone-21-acetate ;11-dehydro-17-hydroxycorticosteroneacetate ;17,21-dihydroxypregn-4-ene-3,11,20-trioneacetate ;4-PREGNEN-17ALPHA,21-DIOL-3,11,20-TRIONE ACETATE;4-PREGNEN-17,21-DIOL-3,11,20-TRIONE 21-ACETATE;4-PREGNENE-17ALPHA,21-DIOL-3,11,20-TRIONE 21-ACETATE;17ALPHA,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE 21-ACETATE
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Brand

  • Sigma-Aldrich(India)

Package

  • 300MG
  • 1G
  • 5G
  • 10G
  • 25G
  • ManufacturerSigma-Aldrich(India)
  • Product numberC3130
  • Product descriptionCortisone 21-acetate ≥99%
  • Packaging1G
  • Price₹6386.75
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1923
  • Product descriptionCortisone Acetate Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging300MG
  • Price₹20621.63
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC3130
  • Product descriptionCortisone 21-acetate ≥99%
  • Packaging5G
  • Price₹24832.55
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC3130
  • Product descriptionCortisone 21-acetate ≥99%
  • Packaging10G
  • Price₹36880.78
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC3130
  • Product descriptionCortisone 21-acetate ≥99%
  • Packaging25G
  • Price₹74270.33
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) C3130 Cortisone 21-acetate ≥99% 1G ₹6386.75 2022-06-14 Buy
Sigma-Aldrich(India) PHR1923 Cortisone Acetate Pharmaceutical Secondary Standard; Certified Reference Material 300MG ₹20621.63 2022-06-14 Buy
Sigma-Aldrich(India) C3130 Cortisone 21-acetate ≥99% 5G ₹24832.55 2022-06-14 Buy
Sigma-Aldrich(India) C3130 Cortisone 21-acetate ≥99% 10G ₹36880.78 2022-06-14 Buy
Sigma-Aldrich(India) C3130 Cortisone 21-acetate ≥99% 25G ₹74270.33 2022-06-14 Buy

Properties

Melting point :237-240 °C(lit.)
Boiling point :577.3±50.0 °C(Predicted)
alpha :D25 +164° (c = 0.5 in acetone); D25 +208 to +217° (dioxane)
Density :1.26±0.1 g/cm3(Predicted)
refractive index :212 ° (C=1, MeOH)
storage temp. :2-8°C
solubility :Practically insoluble in water, freely soluble in methylene chloride, soluble in dioxan, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent) and in methanol.
form :Solid
pka :12.32±0.60(Predicted)
color :White to Off-White
Water Solubility :19mg/L(25 ºC)
Merck :14,2539
BRN :2067543
Stability :Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference :50-04-4(CAS DataBase Reference)
EPA Substance Registry System :Cortisone acetate (50-04-4)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P314 Get medical advice/attention if you feel unwell.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Cortisone acetate is a synthetic glucocorticoid with anti-inflammatory properties. It decreases the size of Bacillus Calmette-Guérin (BCG) vaccine-induced dermal lesions and tuberculin reactions in rabbits when administered at 2 mg/kg on alternate days over the course of 46 days. It also reduces the number and percentage of activated lesion-infiltrating mononuclear cells and decreases the amount of caseous necrosis and ulceration. Cortisone acetate (2.5 mg/kg per day, s.c.) slows tissue regeneration in a rabbit model of wound healing. It also decreases the number of dexamethasone binding sites on isolated human lymphocytes by 30%. Formulations containing cortisone acetate have been used to relieve inflammation, pruritic manifestations of corticosteroid-responsive dermatoses, and in the treatment of immune and allergic disorders.

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