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ChemicalBook > Product Catalogue >API >Specialty drugs >Antidote >DEFEROXAMINE MESYLATE

DEFEROXAMINE MESYLATE

DEFEROXAMINE MESYLATE Structure
  • ₹16367.4
  • Product name: DEFEROXAMINE MESYLATE
  • CAS: 138-14-7
  • MF: C26H52N6O11S
  • MW: 656.79
  • EINECS:205-314-3
  • MDL Number:MFCD00058605
  • Synonyms:deferoxaminebmesylate ;deferoxaminemesilate ;deferoxaminemethanesulfonate ;desferal ;desferalmesylate ;desferalmethanesulfonate ;desferrioxaminebmesylate ;Deferoxamine Mesylate (300 mg)
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Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product numberD9533
  • Product descriptionDeferoxamine mesylate salt powder, ≥92.5% (TLC)
  • Packaging1G
  • Price₹16367.4
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) D9533 Deferoxamine mesylate salt powder, ≥92.5% (TLC) 1G ₹16367.4 2022-06-14 Buy

Properties

Melting point :148-149°
storage temp. :2-8°C
solubility :H2O: 50 mg/mL
form :powder
color :white to off-white
Water Solubility :Soluble to 100 mM in water

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Deferoxamine Mesylate, an iron chelator, has been found to inhibit thymidine incorporation in cell cultures which is antagonized by iron supplementation. Iron has been reported to be involved in the control of enzymatic activities that regulate DNA synthesis in cells. This compound has also been reported to induce apoptosis by causing chromatin condensation. Additionally, Deferoxamine Mesylate demonstrates the ability to induce p53 and cell accumulation in the G1 phase of cell growth and increase p21 mRNA levels without any detectable protein products. Furthermore, studies suggest that this agent is capable of activating HIF-1α (hypoxia-inducible factor 1α), consequently causing transcription of numerous genes that are associated with hypoxia. Deferoxamine Mesylate is an inhibitor of Prolyl Hydroxylase.

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