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ChemicalBook > Product Catalogue >API >Respiratory Drugs >Antitussives >Dextromethorphan

Dextromethorphan

Dextromethorphan Structure
  • ₹0
  • Product name: Dextromethorphan
  • CAS: 125-71-3
  • MF: C18H25NO
  • MW: 271.4
  • EINECS:204-752-2
  • MDL Number:MFCD00866833
  • Synonyms:D-methorphan;Morphinan, 3-methoxy-17-methyl-, (9alpha,13alpha,14alpha)-;Racemethorphan [as d-form];[9α,13α,14α,(+)]-3-Methoxy-17-methylmorphinan;C06947;(+)-3-methoxy-N-methylmorphinan;(+)-cis-1,3,4,9,10,10a-hexahydro-6-methoxy-11-methyl-2H-10,4a-iminoethanophenanthrene;Benylin DM
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :80 °C
Boiling point :414.48°C (rough estimate)
Density :1.0115 (rough estimate)
refractive index :1.5740 (estimate)
Flash point :9℃
storage temp. :-20°C
solubility :Chloroform (Slightly), Methanol (Slightly)
form :Solid
pka :pKa 8.3 (Uncertain)
color :White to Off-White
Water Solubility :12mg/L(temperature not stated)
InChIKey :MKXZASYAUGDDCJ-CGTJXYLNSA-N
CAS DataBase Reference :125-71-3(CAS DataBase Reference)
EPA Substance Registry System :Morphinan, 3-methoxy-17-methyl-, (9?,13?,14?)- (125-71-3)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P391 Collect spillage. Hazardous to the aquatic environment
P405 Store locked up.

Description

Dextromethorphan is an over-the-counter drug that is sold alone and in combination with other products as a cough suppressant for children and adults. We have previously recommended dextromethorphan as a safe and effective cough suppressant for both children and adults. However, the weight of the evidence now suggests that dextromethorphan is no more effective than an inactive placebo syrup in suppressing a nighttime cough in children. It is the disomer of the potent opiate analgesic 3-methoxyN-methylmorphine (levorphanol). Although dextromethorphan is structurally related to opioids, it is devoid of analgesic or sedative effects at therapeutic doses. Dextromethorphan is metabolized by CYP2D6 to a more potent metabolite, dextrorphan. Dextrorphan is a stronger noncompetitive antagonist than dextromethorphan for the N-methyl-D-aspartate (NMDA) glutamate receptor.These properties promote its use in treatment of neuropathic and postoperative pain management.

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Suppliers and manufacturers

KARPSCHEM LABORATORIES Rivashaa Agrotech Biopharma Pvt. Ltd. Alfa Omega Pharma Exemed Pharmaceuticals (Oneiro Chemicals Pvt Ltd) Hy Gro Chemicals Pharmtek Pvt Ltd Divis Laboratories Ltd DIVIS LABORATORIES LTD SynZeal Research Pvt Ltd Pharmaffiliates Analytics and Synthetics P. Ltd Triveni chemicals