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ChemicalBook > Product Catalogue >Biochemical Engineering >Plant extracts >Diosmetin

Diosmetin

Diosmetin Structure
  • ₹7707.4 - ₹98001
  • Product name: Diosmetin
  • CAS: 520-34-3
  • MF: C16H12O6
  • MW: 300.26
  • EINECS:208-291-8
  • MDL Number:MFCD00017425
  • Synonyms:3',5,7-TRIHYDROXY-4'METHOXYFLAVONE;4'-METHOXY-5,7,3'-TRIHYDROXYFLAVONE;4-METHOXY-5,7,3'-TRIHYDROXYFLAVONE;5,7,3'-TRIHYDROXY-4'-METHOXYFLAVONE;DIOSMETIN;5,7-Dihydroxy-2-[3-hydroxy-4-methoxyphenyl]-[4H]-1-benzopyran-4-one;4'-Methylluteolin;Diosmetol
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  • Sigma-Aldrich(India)
  • ottokemi

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  • 10MG
  • 100MG
  • 500MG
  • 1gm
  • ManufacturerSigma-Aldrich(India)
  • Product numberD7321
  • Product descriptionDiosmetin
  • Packaging10MG
  • Price₹7707.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number90985
  • Product descriptionDiosmetin analytical standard
  • Packaging10MG
  • Price₹22353.63
  • Updated2022-06-14
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  • ManufacturerSigma-Aldrich(India)
  • Product numberD7321
  • Product descriptionDiosmetin
  • Packaging100MG
  • Price₹23338.7
  • Updated2022-06-14
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  • ManufacturerSigma-Aldrich(India)
  • Product numberD7321
  • Product descriptionDiosmetin
  • Packaging500MG
  • Price₹43657.23
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number D 2228
  • Product descriptionDiosmetin+ 97%
  • Packaging10mg
  • Price₹8019
  • Updated2022-05-26
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  • Manufacturerottokemi
  • Product number D 2228
  • Product descriptionDiosmetin+ 97%
  • Packaging100mg
  • Price₹24003
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number D 2228
  • Product descriptionDiosmetin+ 97%
  • Packaging500mg
  • Price₹56502
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number D 2228
  • Product descriptionDiosmetin+ 97%
  • Packaging1gm
  • Price₹98001
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) D7321 Diosmetin 10MG ₹7707.4 2022-06-14 Buy
Sigma-Aldrich(India) 90985 Diosmetin analytical standard 10MG ₹22353.63 2022-06-14 Buy
Sigma-Aldrich(India) D7321 Diosmetin 100MG ₹23338.7 2022-06-14 Buy
Sigma-Aldrich(India) D7321 Diosmetin 500MG ₹43657.23 2022-06-14 Buy
ottokemi D 2228 Diosmetin+ 97% 10mg ₹8019 2022-05-26 Buy
ottokemi D 2228 Diosmetin+ 97% 100mg ₹24003 2022-05-26 Buy
ottokemi D 2228 Diosmetin+ 97% 500mg ₹56502 2022-05-26 Buy
ottokemi D 2228 Diosmetin+ 97% 1gm ₹98001 2022-05-26 Buy

Properties

Melting point :256-258°C
Boiling point :576.7±50.0 °C(Predicted)
Density :1.512±0.06 g/cm3(Predicted)
vapor pressure :0Pa at 20℃
storage temp. :Sealed in dry,2-8°C
solubility :Soluble in acetonitrile, DMSO (60 mg/ml), and ethanol (17 mg/ml), clear, light yellow to yellow.
form :Solid
pka :6.50±0.40(Predicted)
color :light yellow to yellow
Water Solubility :19μg/L at 20℃
BRN :294492
Stability :Hygroscopic
InChIKey :MBNGWHIJMBWFHU-UHFFFAOYSA-N
LogP :3.1 at 20℃
CAS DataBase Reference :520-34-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Diosmetin is a natural O-methylated flavone that is structurally related to luteolin . It reversibly inhibits cytochrome P450 (CYP) isoforms 1A1 and 1B1 in human liver microsomes with Ki values of 89 and 16 nM, respectively. It less potently inhibits CYP2C8 and CYP2C9 (Kis = 3.1 and 1.7 μM, respectively). While diosmetin inhibits CYP1A1 activity, it increases the transcription of the CYP1A1 gene in MCF-7 cells by activating the aryl hydrocarbon receptor when applied at 5 μM. Diosmetin also inhibits signaling through the stem cell factor receptor, c-Kit, at micromolar concentrations.

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